The full text of Senior Independent Study Theses submitted during and after 2012 are available to download only by College of Wooster users. Unless listed as an exemplar, all other theses are restricted.

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Senior Independent Study Theses from 2022

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Phenotypic Rescue Of Key Social Behaviors In M. Xanthus By The Desulfotalea Psychrophila Arginine Kinase, Nathaniel J. Arday
Department: Biochemistry and Molecular Biology

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Role Of Tight Binding In Negative Cooperativity In The Dimeric Mitochondrial Taurocyamine Kinase From Arenicola Brasiliensis, Robert M. Beal
Department: Biochemistry and Molecular Biology

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Identification And Detection Of Biomarkers Of Dilated Cardiomyopathy In A Cohort Of Amish Patients With Propionic Acidemia Using High Resolution Mass Spectrometry, Alexa Nicole Bencic
Department: Biochemistry and Molecular Biology

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To Clean Or Not To Clean: Exploring The Ability Of Biocidal Compounds To Induce Physiological Changes In Bacteria That May Increase The Spread Of Antibiotic Resistance Genes, Kayla R. Bertholf
Department: Biochemistry and Molecular Biology

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Boolean Model Of Mesenchymal Cell'S Resistance To Chromosomal Senescence, Arnav Bhatnagar and Erśebet Regan
Department: Biochemistry and Molecular Biology

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Synthesis, Characterization, And Biological Activity Of Silver (I) Fatty Acid Complexes Against Candida Albicans, Macy Faith Bischoff
Department: Biochemistry and Molecular Biology

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The Seven Deadly Pathways: A Boolean Model Of Yeast Apoptosis In Response To Reactive Oxygen Species, DNA Damage, And Salt, Andrea Brown
Department: Biochemistry and Molecular Biology

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Molecular Recognition Within The Es Complex: A Mechanistic Investigation To Discern How 6-Hydroxynicotinate-3-Monooxygenase (Nicc) Distinguishes Between Substrate Analogues When Enhancing Its Rate Of Nadh Oxidation, Joel K. Brown
Department: Biochemistry and Molecular Biology

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“It’S Not Just A Phage, Mom”: An Examination Of Antibiotic Resistance In Pseudomonas Aeruginosa In Response To Bacteriophage Treatment, Kirsten Buchan
Department: Biochemistry and Molecular Biology

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“It’S Not Just A Phage, Mom”: An Examination Of Antibiotic Resistance In Pseudomonas Aeruginosa In Response To Bacteriophage Treatment, Kirsten N. Buchan
Department: Biochemistry and Molecular Biology

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Effects Of Xenobiotic Pollution On Histopathological Alterations And Cyp1A Expression On Brown Bullhead (Ameiurus Nebulosus) In Wooster, OH, Madison A. Crucs
Department: Biochemistry and Molecular Biology

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The Virome Of Aedes Japonicus And Culex Spp., Collected In Wooster, Oh, Usa, Alexander R. DeLong
Department: Biochemistry and Molecular Biology

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Biochemical Analysis Of The Myxococcus Fulvus 124B02 Arginine Kinase, Krista L. English
Department: Biochemistry and Molecular Biology

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Analysis Of The Antimicrobial Activity Of The Novel Chemotherapeutic Drug, Tpp1, Against Pseudomonas Aeruginosa And The Hydrogel Delivery Of Water-Soluble Antimicrobial Compounds, Alex Gasper
Department: Biochemistry and Molecular Biology

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Advances In Characterizing The Gene-Encoded Subunits That Compose The Nicotinate Dehydrogenase And 6-Hydroxynicotinate Dehydrogenase Enzyme Complexes Within The Bacillus Niacini Nicotinic Acid Degradation Pathway, Emilee R. Haines
Department: Biochemistry and Molecular Biology

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Investigating Substrate Specificity For 6-Hydroxynicotinate 3- Monooxygenase (Nicc) With Alternative Substrates: Consequences To Catalysis Of Replacing Or Removing The Ring Nitrogen, May Zin Hlaing
Department: Biochemistry and Molecular Biology

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Characterization Of A Potential Novel Redox Partner In S. Cerevisiae Mitochondrial Disulfide Relay System And In Silico Elucidating Its Essentiality, Thinh Huynh
Department: Biochemistry and Molecular Biology

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The Influence Of Silver (I) Carboxylate Ligand Structure On Antimicrobial Activity In Pseudomonas Aeruginosa, Kylie E. Keller
Department: Biochemistry and Molecular Biology

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Synthesis, Characterization, And Antimicrobial Activity Of Folic Acid And Glutamic Acid Derived Silver (I) Compounds Against Pseudomonas Aeruginosa, Benjamin James Kennedy
Department: Biochemistry and Molecular Biology

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Synthesis, Characterization, And Antimicrobial Activity Of Folic Acid And Glutamic Acid Derived Silver (I) Compounds Against Pseudomonas Aeruginosa, Benjamin James Kennedy
Department: Biochemistry and Molecular Biology

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Synthesis, Characterization, And Antimicrobial Activity Of Folic Acid And Glutamic Acid Derived Silver (I) Compounds Against Pseudomonas Aeruginosa, Benjamin James Kennedy
Department: Biochemistry and Molecular Biology

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Advances In The Elucidation Of The Nicotinic Acid Degradation Pathway In Bacillus Niacini: Proof Of Formation Of The Trihydroxypyridine Intermediate And The Characterization Of An Fmn-Dependent Flavoprotein Of Unknown Function, Sai Kwan Khal
Department: Biochemistry and Molecular Biology

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Examining The Role Of Arginine Kinase In The Social And Physiological Processes Of Myxococcus Xanthus, Lillian R. MacLean
Department: Biochemistry and Molecular Biology

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Following The Lead: Impact Of Soil Amendments On Lead Toxicity To Tomato, Alicia McElwee
Department: Biochemistry and Molecular Biology

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The Effect Of Adipokinetic Hormone (Akh) On Fecundity Of Aedes Aegypti Mosquitoes., A'Janay C. Nicholson
Department: Biochemistry and Molecular Biology

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The Effect Of Adipokinetic Hormone (AKH) On Fecundity Of Aedes Aegypti Mosquitoes., A'Janay C. Nicholson
Department: Biochemistry and Molecular Biology

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Examining The Effects Of Angiotensin I-Converting Enzyme On The Fecundity Of Female Aedes Aegypti Mosquitoes, Daphne Lynn Pate
Department: Biochemistry and Molecular Biology

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Allelochemical In Situ Evaluation Of A Swellable Organically Modified Silica Based Sampler Using Lc-Ms/Qtof, Damien M. Sausville and Paul L. Edmiston
Department: Biochemistry and Molecular Biology

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Investigating Whether The Rna Binding Protein Nab2 Regulates Tau Mrna Levels In A Fly Model Of Neurodegeneration, Emma Grace Schwinne
Department: Biochemistry and Molecular Biology

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Boolean Modeling Of The Interactions Between Inflammation, Hypoxia, And The Epithelial-Mesenchymal Transition (Emt), Ian Zonfa
Department: Biochemistry and Molecular Biology

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Characterization Of The Natural Antibiotic Activity Of Pseudomonas Environmental Isolates, Harrison Zwolshen
Department: Biochemistry and Molecular Biology

Senior Independent Study Theses from 2021

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The Female Perspective: An Investigation Into How the Reconstruction and Efficacy of a Gynecological Fertility Recipe Unveils Female Voice in the Hippocratic Corpus, Randa Elie Abboud
Department: Biochemistry and Molecular Biology; Classical Studies; History

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Maternal and Infant Factors That Influence Infant Microbiome Composition and Microbial Fucose Utilization, Grace E. Adkins
Department: Biochemistry and Molecular Biology

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Investigating the Effects of the Phone a STEM Professional Assignment on STEM Students’ Sense of Belonging, Career Confidence, and Career Awareness, Kyla M. Babics
Department: Biochemistry and Molecular Biology

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Simulating Mammalian Liver Homeostasis and the Impact of Senescence, Stuart Ryan Ball
Department: Biochemistry and Molecular Biology

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Reconstitution of Hydroxylation Activity of Recombinant NDH and 6-HDH Complexes from Bacillus niacini, Luke Borgelt
Department: Biochemistry and Molecular Biology

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Searching for Novel Redox Partners of the Mitochondrial Protein Erv1, Camryn A. Bragg
Department: Biochemistry and Molecular Biology

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Investigation of the Metabolic Role of Triosephosphate Isomerase (TPI) in the Physiological function of Myxococcus xanthus, Sienna F. Carr
Department: Biochemistry and Molecular Biology

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Elucidating Phosphagen Kinase Evolution through the Identification of Substrate Specific Arginine Kinases and Taurocyamine Kinase within Platyhelminthes, Emmalee Cooke
Department: Biochemistry and Molecular Biology

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Investigating the Efficacy of RNAi for Use in the Study of Caenorhabditis elegans Arginine Kinase, Evan Thomas Faxon
Department: Biochemistry and Molecular Biology

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Establishing a Functional Heterologous Expression System for Bacillus niacini Nicotinate Dehydrogenase and 6-Hydroxynicotinate Dehydrogenase Using Escherichia coli, Daniel T. Fleming
Department: Biochemistry and Molecular Biology

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Using a Protein Cross-Linker to Confirm Protein Disulfide Isomerase Interactions and Impact on Downstream Processes, Wilson M. Freije
Department: Biochemistry and Molecular Biology

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Tentative Detection of Phosphoarginine by LC-MS in M. xanthus, Asvin Gireesh
Department: Biochemistry and Molecular Biology

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Purification and Crystallization of MurG: Towards Structural Characterization of a Ubiquitous Antibiotic Target, Peter E. Greenwood Jr
Department: Biochemistry and Molecular Biology

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A Boolean Model of Crosstalk Between Senescence and Epithelial to Mesenchymal Transition, Marlayna Harris
Department: Biochemistry and Molecular Biology

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Homology Modeling and Protein-Ligand Structural Analysis of the Bacillus niacini NicAB Protein Complex, Wenhao Hu
Department: Biochemistry and Molecular Biology

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Layer up: An investigation of yeast flocculation in the context of genetic, environmental, and cell wall composition effectors, Brieanna Jarrell
Department: Biochemistry and Molecular Biology

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Polymicrobial Competition: Bacteria and Fungi Compete Using a Unique Toxin Secreted Through the Type VI Secretion System, Olivia Johnson
Department: Biochemistry and Molecular Biology

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An Examination of Antibiotic Resistance Genes in Pseudomonas chlororaphis in Response to Bacteriophage Therapy, Eric Kraus
Department: Biochemistry and Molecular Biology

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Evidence of Negative Cooperativity in Cytosolic Taurocyamine Kinase from Arenicola brasiliensis and its Implication in the Evolution of the Phosphagen Kinase Family, Mingyuan "Merlin" Li
Department: Biochemistry and Molecular Biology

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Deciphering the “Logic Puzzle” of Traditional Chinese Herbal Medicine: Investigating Cooperative Protective Effects of Artemisinin and Hyperoside Against Oxidative Damage in Saccharomyces cerevisiae, Kejun Liu
Department: Biochemistry and Molecular Biology

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Phenotypic and Biochemical Analysis of Active Site Variation in Thioredoxin: A Conserved Oxidant Defense Protein Responsible for Disulfide Bond Reduction in Cells, Eran N. Maina
Department: Biochemistry and Molecular Biology

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Elucidating the Biodegradative Pathway of Nicotinic acid by Bacillus Niacini: Defining the Biochemical Action of Bn DUF, Connor Thomas Mangan
Department: Biochemistry and Molecular Biology

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Host Domination: Characterizing Pseudomonas chlororaphis Bacteriophage’s Host Range and Binding Receptors, Marissa E. Norgrove
Department: Biochemistry and Molecular Biology

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Effect of Adipokinetic Hormone on Mating Receptivity of Aedes aegypti Females, Dhwani Parsana
Department: Biochemistry and Molecular Biology; Neuroscience

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Investigating the Selective Advantages and Microenvironmental Requirements of Cellular Clustering Utilizing an Agent-Based Model of Yeast Flocculation, Alyssa N. Ramirez
Department: Biochemistry and Molecular Biology

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Characterization of Substrate Promiscuity for 6-Hydroxynicotinate 3-Monooxygenase: A Transient Kinetic Investigation of the Decarboxylative-Hydroxylation of 5-Chloro-6-Hydroxynicotinic Acid, Jack Charles Redick
Department: Biochemistry and Molecular Biology

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Stem Cell Research from 1990s – Present: The Development of iPSCs as a Response to Ethical Dilemma Surrounding Extraction of hESCs and Elucidating the Effect of Mechano-sensitivity during the First Differentiation Event of ESCs using Boolean Modeling., Hikmet A. Sherief
Department: Biochemistry and Molecular Biology; History

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Impact of Active Site Motif Mutations on Yeast Thioredoxin 2 Activity, Shayna L. Vicker
Department: Biochemistry and Molecular Biology

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Investigating the Role of cAMP in the Sleep Phenotype of the Drosophila Fragile X Syndrome Model, Miura Wiley
Department: Biochemistry and Molecular Biology

Senior Independent Study Theses from 2020

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Venom Self-Degradation: Active Peptide Breakdown by A. compressa Neprilysin to Facilitate Hypokinesia, James M. Alltop
Department: Biochemistry and Molecular Biology

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Impact of CXXC Motif Variation on the Function of the Yeast Thioredoxin Trx2, Morgan Bailey
Department: Biochemistry and Molecular Biology

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Analysis of Salmonella and Listeria Localization in a Hydroponic System and the Effects of pH Reduction on Pathogenic Growth, Michelle Biksey
Department: Biochemistry and Molecular Biology

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Seminal Fluid-Derived Adipokinetic Hormone (sfAKH) Influences Mating Behavior in Female Aedes aegypti with Observations on Accessory Reproductive Glands, Gemma Briggs
Department: Biochemistry and Molecular Biology; Neuroscience

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Investigation of Phytophthora sojae’s RxLR effectors on the MAPK pathway in Saccharomyces cerevisiae, Michelle Chang
Department: Biochemistry and Molecular Biology

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Zombie Cockroaches: Emerald Jewel Wasp Venom-Derived Neuropeptide Tachykinin Modulates Neuronal Cells of the American Cockroach, Spencer Michael Coffman
Department: Biochemistry and Molecular Biology

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Impact of Various Degradation Pathways on Ribonucleotide Reductase Inhibitor Hug1 Stability in Saccharomyces Cerevisiae, Jason N. Constable
Department: Biochemistry and Molecular Biology

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Analysis of Bacteria - Host Interactions between Caenorhabditis Elegans and Unexplored Bacteria, Harrison G. Davenport
Department: Biochemistry and Molecular Biology

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Toxicity Analysis of OGT Inhibitor Et-OSMI-2 Against Strains of E. coli and Pseudomonas, Craig Deng
Department: Biochemistry and Molecular Biology

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Differential Expression Analysis of the Nic Cluster and Attempts at Characterizing the Nicab Complexes in the Novel Nicotinic Acid Degradation Pathway of Bacillus Niacini, Anh Dinh
Department: Biochemistry and Molecular Biology

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Impact of Tsa1 Subcellular Localization on its Biological Function, Daniel Dorman
Department: Biochemistry and Molecular Biology

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Barely Scratching the Surface: Examining the Relationship between Carotenoid Pigment and Immunity of Betta splendens with Bco1, Samantha B. Draves
Department: Biochemistry and Molecular Biology

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Wash Your Hands, You Filthy Animals! An Exploration of the Presence of Antibiotic Resistance Genes in Non-Clinical Settings, Ana R. Fairbanks-Mahnke
Department: Biochemistry and Molecular Biology

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Using the Protein Cross-Linker Divinyl Sulfone to Identify the Putative Client Proteins of Protein Disulfide Isomerases and Its Effects on ER Homeostasis, Benjamin Freije
Department: Biochemistry and Molecular Biology

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Caenorhabditis elegans' Use of Apoptosis in the Immune Response to Pseudomonas Bacterial Infections, Daniel Gail
Department: Biochemistry and Molecular Biology

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No Need to Stress: The Effects of Protandim Supplementation on Counteracting Oxidative Stress via the Nrf2 Pathway, Kelsey Taylor Hall
Department: Biochemistry and Molecular Biology; Neuroscience

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Mosquitoes Bloody Suck!: Identifying Potential Vectors and Non-Human Hosts of Mosquito-Borne Pathogens in Alajuela, Costa Rica, Emma R. Hambright
Department: Biochemistry and Molecular Biology; Neuroscience

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Progress in Characterizing a Novel Root Exudate: Differential gene expression of Bacillus niacini DSM 2993 in Response to Nicotinic Acid through RNA-seq, Noah S. Helton
Department: Biochemistry and Molecular Biology

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Exploring Peptidoglycan Synthesis: Assessing the Viability of NagZ as a Potential Tool for Obtaining Lipid I, Robert Hunt
Department: Biochemistry and Molecular Biology

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Computational Analysis of PsAvh172 Data to Investigate the Targets of Phytophthora sojae in Soybean Host A Hierarchical Clustering Evaluation of Yeast RNA-Seq Data, Vi Huynh
Department: Mathematics; Biochemistry and Molecular Biology

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Understanding the transcriptional control of a late expressing gene (BV1) of mungbean yellow mosaic virus (MYMV), Sung Won Kang
Department: Biochemistry and Molecular Biology

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Investigating Changes in Protein Ubiquitylation following Sleep Deprivation in Drosophila melanogaster, Koral Kasnyik
Department: Biochemistry and Molecular Biology

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Organic Synthesis of Potential Small-Molecule Inhibitors for MurG: A Research Tool for Investigating Cell Wall Biosynthesis in Bacteria, Matthew J. Mahoney-White
Department: Biochemistry and Molecular Biology

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Active Site Variants of Yeast Thioredoxin 2: An Analysis of Biological Function, Enzymatic Activity, and Redox Partner Interactions, Stephen W. McGarry
Department: Biochemistry and Molecular Biology

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The Identification and Characterization of a Halophilic UvrD Homologue, and its Incorporation into Helicase Dependent Amplification, Kevin Miller
Department: Biochemistry and Molecular Biology

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Genetic Control of Neural Development: An RNA-Sequencing Approach to Reveal dNab2 mediated Differential Gene Expression in D. melanogaster, Gargi Mishra
Department: Biochemistry and Molecular Biology

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The Glow Up: An Investigation into Methods for Improving the Photostability of Fluorescent Proteins TagRFP657 and TurboGFP, Morgan A. Mooty
Department: Biochemistry and Molecular Biology

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Analysis of Saccharomyces cerevisiae transcription factor PHO4 localization when exposed to Phytophthora sojae effector protein PsAvh110, Alex Morris
Department: Biochemistry and Molecular Biology

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Investigating the Role of Phytophthora Sojae Effectors in Suppressing a Hosts Immune Response, Paulo S. Nunes Maldonado
Department: Biochemistry and Molecular Biology

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Determining the Infection Specificity of Bacteriophage Therapy in Multi-Species Biofilms, Mackenzie L. Owen
Department: Biochemistry and Molecular Biology

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Swapping the N-termini of Mitochondrial and Cytoplasmic Taurocyamine Kinase from Arenicola brasiliensis in order to Study the Importance of the Interactions Between the N and C Termini in Controlling Substrate Binding and Specificity, Brent N. Pederson
Department: Biochemistry and Molecular Biology

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The Binding and Kinetic Mechanisms of 6-Hydroxynicotinate 3-Monooxygenase (NicC), A Decarboxylative Hydroxylase Involved in Nicotinate Degradation, Scott W. Perkins
Department: Biochemistry and Molecular Biology

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Mutational Analysis of Putative Ubiquitination Sites in the Ribonucleotide Reductase Inhibitors Sml1and Dif1, Hunter T. Pierson
Department: Biochemistry and Molecular Biology

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The Role of Adipokinetic Hormone in female Aedes aegypti mosquitoes Bloodmeal Digestion, Zainab Moyosore Saliu
Department: Biochemistry and Molecular Biology

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Expression, Purification, and Crystallization of S. aureus MurG: Towards Structural Characterization of a Putative Antibiotic Target, Leman WI Simpson
Department: Biochemistry and Molecular Biology; Chemistry

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Characterization of Ampulex compressa Venom Adenosine Deaminase That Superimposes and Antagonizes Purinergic Signaling in Periplaneta americana, Garrett S.D. Tinline
Department: Biochemistry and Molecular Biology

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Moorea Than You Bargained For: The Attempted Confirmation and Characterization of a Novel Arginine Kinase in Moorea producens, Anneliese C. Wagoner
Department: Biochemistry and Molecular Biology

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Seeing Color a Little Betta: Investigating the role of tyr in melanin-based phenotypic variation in Betta splendens, Sierra Weir
Department: Biochemistry and Molecular Biology

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Synthesis of Novel Fluorescent Unnatural Amino Acid Using Fluorophore from EVOblue 30 Fluorescent Dye, Meghan K. Wells
Department: Biochemistry and Molecular Biology

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Mind Control? Immunohistochemical Analysis of Tachykinin Receptor and GABAergic Neurons in the Cephalic Ganglia of the Cockroach Brain, William J. Yakubik III
Department: Neuroscience; Biochemistry and Molecular Biology