Senior Independent Study Theses from 2015
Exploring the Structural Basis for Negative Cooperativity in the Phosphagen Kinase Superfamily, Gentry Jarrett Kerwood
Department: Biochemistry and Molecular Biology
Modification of Saccharomyces cerevisiae oxidant defense proteins by the electrophiles N- ethylmaleimide and parthenolide, Karis Kosar
Department: Biochemistry and Molecular Biology
Inhibition and Kinetic Isotope Effect Studies to Further Characterize the Mechanism of Maleamate Amidohydrolase (NicF), Karan Malani
Department: Biochemistry and Molecular Biology
Cloning, Purification, and Analysis of an Aromatic Monooxygenase Protein Involved in the Production of Strain-Specific Phenazine Metabolites, Edmund W. Shi
Department: Biochemistry and Molecular Biology
Preliminary Investigation of Arginine Kinase in Caenorhabditis elegans, Dempsey J. Simonis
Department: Biochemistry and Molecular Biology
A Screen for S. cerevisiae Mutants Hypersensitive to the P. sojae effector PsAvh172, Matthew J. Sydor
Department: Biochemistry and Molecular Biology
Senior Independent Study Theses from 2014
Transcriptional Response to the Phytophthora Sojae Avh110 Effector Protein Using a Yeast Expression Study, Gabriel J. Abud
Department: Biochemistry and Molecular Biology
Investigating the Effects of Small Molecule Inhibitors of Potassium Channels on Mortality Rate and Urine Excretion in Female Aedes aegypti, Sheila O. Amoako
Department: Biochemistry and Molecular Biology
Evolution of Negative Cooperativity in Phosphagen Kinases, Manish Aryal
Department: Biochemistry and Molecular Biology
Electrophilic Modification of Methionine Sulfoxide Reductases - Mxr1 and Ykg9 from Baker's Yeast, Juliet Chepngeno
Department: Biochemistry and Molecular Biology
A Scientific Paradigm Shift from Reductionism to Holism: The Potential Relationship between Nicotinate Degradation and Virulence Modulation in Bordetella pertussis, Pailin Chiaranunt
Department: Biochemistry and Molecular Biology; Philosophy
Examining a Role for Thioredoxin in Protecting Against Protein Damage by Isothiocyanate-Containing Electrophiles, Sreyan Chowdhury
Department: Biochemistry and Molecular Biology
An Analysis of the Bioremediaiton of Venlafaxine, James B. Claybourne IV
Department: Biochemistry and Molecular Biology
LC-MS/MS Analysis of Fluoxetine and Serotonin-Related Compounds in Eisenia Fetida Living in Treated Soil, Maria Dawaher
Department: Biochemistry and Molecular Biology; Chemistry
Effect of Growth Selection on Adipogenic Gene Expression in Turkey Breast Muscle, Kory K. George
Department: Biochemistry and Molecular Biology
Molecular Biology of a Miracle: Conceptualization of Medicine Through the Amish-Religious Lens and Antimicrobial Properties of Burdock Burn Wound Treatment, Caroline H. Gormley
Department: Biochemistry and Molecular Biology; Religious Studies
An Investigation of the Inhibition of Phenazine Biosynthesis in Pseudomonas, Holly M. Jacobs
Department: Biochemistry and Molecular Biology
Assessment of the Biocontrol Activity of Mitsuaria Isolates Through Indole-3-acetic Acid Regulation and Plant Pathogen Inhibition, Christine M. Kasprisin
Department: Biochemistry and Molecular Biology
Elucidation of Bordetella bronchiseptica Maleamate Amidohydrolase (NicF) Substrate Specificity, Helena M. Kondow
Department: Biochemistry and Molecular Biology
Using Cultivation-Independent Methods to Investigate Venlafaxine Biodegradation, Zena Lapp
Department: Biochemistry and Molecular Biology
Exploring a Role for Thioredoxin in the Recognition of Electrophilic Modifications in Substrate Proteins, Matthew Naticchia
Department: Biochemistry and Molecular Biology
Developing Swellable Organically Modified Silica as a Drug Delivery System for Proteins, Austin Oberlin
Department: Biochemistry and Molecular Biology
Investigating the In Vitro Binding Interactions of Dbp6 and Two Potential Protein Cofactors in 60S Ribosomal Biogenesis, William P. Pender III
Department: Biochemistry and Molecular Biology
Identifying a Novel Host Target of the Pytophthora sojae RxLR Effector Protein PsAvh172, Matthew S. Reeder
Department: Biochemistry and Molecular Biology
Mechanistic Examination of the Mutator Phenotype in Saccharomyces cerevisiae Lacking the Peroxiredoxin Thioredoxin Peroxidase 1, Trevor J. Roston
Department: Biochemistry and Molecular Biology
Preliminary Investigations into the Essential Region of DEAD-Box Protein 6, Zachary BC Rotter
Department: Biochemistry and Molecular Biology
The Development of a Non-Surgical Sterilant for Dogs, Erica Skillman
Department: Biochemistry and Molecular Biology
Pertusiss, Pellagra, and Poverty: A Historical and Scientific Analysis of Whooping Cough's Associations with Poverty and Pellagra, and the Nicotinate Degradation Pathway in Bordetella Pertussis, Jacob Sprano
Department: Biochemistry and Molecular Biology; History
Developing an Effective Vaccine for Porcine Reproductive and Respiratory Virus (PRRSV), John M. Thompson
Department: Biochemistry and Molecular Biology
Disrupting Dimer Formation in the Baker’s Yeast Alkyl Hydroperoxide Reductase 1 (Ahp1), Susmit Tripathi
Department: Biochemistry and Molecular Biology
Senior Independent Study Theses from 2013
Characterization of Two Contiguous-Dimer Taurocyamine Kinases From the Parasitic Trematodes Schistosoma Japonicum and Clonorchis Sinensis, Brittany Begres
Department: Biochemistry and Molecular Biology
A Preliminary Analysis of the Differences in Cyclosporin a Resistance Between Amino Acid Residues P538 and P540 of the Hepatitis C Polymerase, Alexandra Kuzmishin
Department: Biochemistry and Molecular Biology
Protective Role of the Yeast Peroxiredoxin Tsa1 Against Electrophile-Mediated Stress, Andrew Lamade
Department: Biochemistry and Molecular Biology
Size Selective Dna Purification Using Swellable Organically Modified Silica, Brian Alexander Lupish
Department: Biochemistry and Molecular Biology
Shedding Light on the DEAD: Preliminary Investigation Into Dbp6, a DEAD-box Protein Required For Ribosome Assembly, Kari Martyniak
Department: Biochemistry and Molecular Biology
Investigating Cis-Elements of Microtubule-Associated Protein Tau's 3'-Untranslated Region, Daniel Montagna
Department: Biochemistry and Molecular Biology
Investigation of Functional Roles For Thioredoxins in Protecting Against Reversible Electrophile Induced Protein Damage in Saccharomyces Cerevisiae, Wesley J. Murphy
Department: Biochemistry and Molecular Biology
Characterization of a Creatine Kinase Enzyme From Cryptosporidium Muris, Paige Piper
Department: Biochemistry and Molecular Biology
Protein Cross-Linking As a Mechanism of Cytotoxicity For Bifunctional Electrophiles, Nikolai Radzinski
Department: Biochemistry and Molecular Biology
Assessing the Ability of Environmental Microbes to Catabolically Degrade the Antidepressant Venlafaxine (Effexor®), Kathryn Clare Sullivan
Department: Biochemistry and Molecular Biology
The Impact of Formate on the Physiology of Campylobacter jejuni, Michael T. Terribile
Department: Biochemistry and Molecular Biology; Neuroscience
Characterizing the Role of 2-Oh-Pca in P. Chlororaphis Pathogenesis, Abigail Toothman
Department: Biochemistry and Molecular Biology
Protein Drug Delivery Using Swellable Organically Modified Silica, Stephen Wanner
Department: Biochemistry and Molecular Biology
Senior Independent Study Theses from 2012
Glycogen Synthase Kinase-3 Regulates DNA Methylation Near Genes Implicated in Bipolar Disorder, Colleen Marie Bartman
Department: Biochemistry and Molecular Biology
Arginine Kinase of Myxococcus Xanthus Influences Development in a Manner Dependent on the Conditions of Development, Thomas Bohl
Department: Biochemistry and Molecular Biology
Influence of the Protein Cross-Linker Diethyl Acetylenedicarboxylate on 20S Core Particle Degradation of Candidates for the 26S Proteasome, TeQuion M. Brookins
Department: Biochemistry and Molecular Biology
Alterations in the Activity of the Yeast Peroxidase Tsa1 Upon Modification By Alkylating Agents, Haley A. Brown
Department: Biochemistry and Molecular Biology
Isolation of Bacterial Strains in Wastewater Sludge Capable of Degradation of Sertraline, Venlafaxine and Triclocarban, Jonathan Fox
Department: Biochemistry and Molecular Biology
Burdock Leaves: Cellular and Antimicrobial Effects in Burn Wound Treatment, Kelsie L. Herring
Department: Biochemistry and Molecular Biology
Evolutionary Study of the Phosphagen Kinase Enzyme Family Probing Substrate Specificity and Cooperativity in Software Derived Ancestral Proteins, Eric Johnson
Department: Biochemistry and Molecular Biology
Investigation of the Potential Role of 6-Hydroxynicotinate-3-Monooxygenase in the Modulation of Virulence in Bordetella Pertussis, Samantha Justice
Department: Biochemistry and Molecular Biology
Progress Towards the Characterization of a Novel Substrate-Analog Inhibitor of Udp-3-O-(R-3-Hydroxymyristoyl)-N-Acetylglucosamine Deacetylase, Emily Christine Linville
Department: Biochemistry and Molecular Biology
Investigation Into the Catalytic Mechanism of Maleamate Amidohydrolase (NicF) from Bordetella Bronchiseptica RB50, Jeffrey Noel
Department: Biochemistry and Molecular Biology
Generation of Thioredoxin 1 and Thioredoxin 2 Mutants in S. Cerevisiae and a Philosophical Investigation of the Ethical Implications of Human Genetic Engineering, Logan D. Pry
Department: Biochemistry and Molecular Biology; Philosophy
Entrapment and Determination of Lipase Embedded in Swellable Organosilica, Modeling Particle Aggregation and Aging of Colloidal Sol-Gels, Kemar Reid
Department: Biochemistry and Molecular Biology
Probing the Role Cysteine-150 in Maleamate Amidohydrolase (NicF) Catalysis From Bordetella Bronchiseptica RB50 By Site-Directed Mutagenesis, Nicholas Spittle
Department: Biochemistry and Molecular Biology
Identification and Characterization of HAP1, a YAP1 Homologue, in the Fungus Histoplasma Capsulatum, Blain Tesfaye Fente
Department: Biochemistry and Molecular Biology
Computational Profiling and Identification of the 3' Untranslated Region Within Paramecium Tetraurela, Tristan Vrolijk
Department: Biochemistry and Molecular Biology; Computer Science
Mapping Polyprotein Cleavage Sites in the R78 Region of Maize Chlorotic Dwarf Virus, Yujing Zhao
Department: Biochemistry and Molecular Biology
Senior Independent Study Theses from 2011
Investigating the Localization and Function of the Prodomain of Neuronal Interleukin-16 on N1E-115 Cells, Cassondra Agozzino
Department: Biochemistry and Molecular Biology
Influence of Proteasome Inhibition on the Baker's Yeast Transcription Factor Yap1p Following Its Activation By Organic Electrophiles, Omar Atassi
Department: Biochemistry and Molecular Biology
Investigation of a Putative Arginine Kinase From Desulfobacterium Autotrophicum: Evolutionary Implications For the Bacterial Arginine Kinases, Christopher DeMoll
Department: Biochemistry and Molecular Biology
Investigating the Role of Threonine-58 in Creatine Kinase Activity and Active Site Communication, Dmytri Eck
Department: Biochemistry and Molecular Biology
Developing a Mechanistic Proposal For 2,5-Dihydroxypyridine-5,6-Dioxygenase (NicX) from Bordetella Bronchiseptica, Matthew Henke
Department: Biochemistry and Molecular Biology
A Study of the Structure/Function Relationship of NicF in the Bordetella Bronshiseptica Nicotinic Acid Degradation Pathway, Roger Klein
Department: Biochemistry and Molecular Biology
Method Development For Quantitative Analysis of Prostanoids and Isoprostanes in Human Serum to Investigate the Molecular Basis of Aspirin Resistance, Mary Kate Lockhart
Department: Biochemistry and Molecular Biology
Organosilica-Polymer Composit Materials For Capture and Release of DNA for Forensic Application, Laszio Marcze
Department: Biochemistry and Molecular Biology
Thermodynamic and Infrared Spectroscopic Study of the Excited State Intramolecular Charge Transfer of 4-Aminobenzoic Acid and 4-Dimethylaminobenzoic Acid, Zachery Matesich
Department: Biochemistry and Molecular Biology
Analysis and Characterization of Siphonosoma Cumanense HTK: Evolutionary Implications, Robert Mayer Jr
Department: Biochemistry and Molecular Biology
The Characterization of a Hybrid Histidine Kinase in the Pathogenic Dimorphic Fungus Histoplasma Capsulatum, Mary Rebecca Moreci
Department: Biochemistry and Molecular Biology
An Investigation of the Ability of Pseudomonas Fluorescens to Degrade the Antidepressent Sertraline (Zoloft®), Brad Palanski
Department: Biochemistry and Molecular Biology
Identification of Genes That Provide Cellular Protection Against a Thiol Cross-Linking Agent in Saccharomyces Cerevisiae, Chelsea Stamm
Department: Biochemistry and Molecular Biology
Characterization of Siderophore Transporters Abc1 and Mfs1 in Histoplasma Capsulatum Pathology, Emily Weitz
Department: Biochemistry and Molecular Biology
Evidence of Subfunctionalization in the Calcineurin Gene Family in Paramecium Tetraurelia, Jordan Welker
Department: Biochemistry and Molecular Biology
Senior Independent Study Theses from 2010
Viral Pathogen Removal From Water Using Swellable Organically Modified Silica, Emily J. Barth
Department: Biochemistry and Molecular Biology
Differential Gene Expression of H. Bacteriophora TTO1 in Response to Heat Stress, Marc Christian
Department: Biochemistry and Molecular Biology; Mathematics
Identifying Genes Required For Growth in Histoplasma Capsulatum Under Osmotic Stress Conditions, Angela Grass
Department: Biochemistry and Molecular Biology
Chemical Analysis of Materials Used to Create the Paint Found on the College of Wooster's Egyptian Coffin, Kimberly Anne Krall
Department: Biochemistry and Molecular Biology
Capacity For Microbial Biomass to Be Used in Biological Control to Manage Plant Pathogen Growth: Advancement of Pseudomonas Flourescens Strain Wayne1R As a Biocontrol Agent Through Identification of Novel Biocontrol Genes, Seth A. Maurer
Department: Biochemistry and Molecular Biology
Expression and Characterization of Phytophthora Sojae Phosphagen Kinases, Allyson Kaitlin Palmer
Department: Biochemistry and Molecular Biology
Nad Catabolism: Identification of a 6-Hydroxynicotinate 3-Monooxygenase in Bordetella Bronchiseptica, Ryan Wilson Story
Department: Biochemistry and Molecular Biology
Effects of Neuregulin-1 on Long Term Potentiation in Cerebellar Granule Cells in Vitro, Andrew Trembath
Department: Biochemistry and Molecular Biology
Senior Independent Study Theses from 2009
Investigating the Use of Oral Creatine Supplementation As a Means of Treatment For the Symptoms of Fibromyalgia Syndrome, Valerie Marie Andrus
Department: Biochemistry and Molecular Biology
Using GFP Fusion Proteins to Screen For the Subcellular Localization of Phytophthora Infestans RXLR Effectors in Host Cells, Samantha Jo Armintrout
Department: Biochemistry and Molecular Biology
Investigating the Role of the IQ67 Domain in the Interaction Between SUN and Calmodulin: An Endeavor Into the Treacherous World of Protein Expression Via Escherichia Coli, Stephanie Louise Edmisson
Department: Biochemistry and Molecular Biology
Microbial Degradation of Triclosan Within Wastewater Treatment Plants, Sarah Gollwitzer
Department: Biochemistry and Molecular Biology
Characterizing the Role and Function of Two Hybrid Histidine Kinases in Histoplasma Capsulatum, Daniel W. Grangaard
Department: Biochemistry and Molecular Biology
DNA Geometry and Its Biological Significance, Lorna Johnston
Department: Biochemistry and Molecular Biology; Mathematics
Using Computational Genomics to Develop a General Gene Model For the Plant Pathogen Phytophthora Infestans, Michael Kwan
Department: Biochemistry and Molecular Biology
A 31P-NMR Study to Determine the Structure of Nanodispersions in Contrast to the Standard Bi-Layer of Liposomes, Marcus T. Liotta
Department: Biochemistry and Molecular Biology
Fusing Interstices: Exploring the Relationship Between Science and Religion in Theory, in Particular Relgious Scientists and in Self, Elise A.G. Meyers
Department: Biochemistry and Molecular Biology; Religious Studies
Characterization of a Putative Monooxygenase Involved in Nad Catabolism, Theodore Carlton Moore, III
Department: Biochemistry and Molecular Biology
Don't Fret the Exchange Rate: the Study of Subunit Exchange Between Oligometric Complexes of ZmHsp17.0-CII Using Fluorescence Resonance Energy Transfer, Chris T. Nau
Department: Biochemistry and Molecular Biology
Investigating the Difference Between Archaeal and Eukaryal Nucleosomal Exchange Using Fluorescence Resonance Energy Transfer, Brittany L. Pitrone
Department: Biochemistry and Molecular Biology
Invitro Inhibition of Matrix Metalloproteinase 9 in Human Breast Cancer Cells, Luke A. Stetzik
Department: Biochemistry and Molecular Biology
Increased Glucagon-Like Peptide-1 (GLP-1) in Type II Diabetics: Results of a High-Fiber Plant-Based Diet, Elizabeth Bailey Wakefield
Department: Biochemistry and Molecular Biology
Senior Independent Study Theses from 2008
Purification of Protected Cyclohexyl Phospho Carbobenzyloxy-L-Serine Benzyl Ester and the Synthesis and Purification of Deprotected Cyclohexyl Phospho-L-Serine Which Is a Potential Analog of Phosphatidylserine, Nicholas Jay Amato
Department: Biochemistry and Molecular Biology
An Investigation Into the Role of Creatine in Muscle Toxicity Associated With Statin-Use, Jason Bowie
Department: Biochemistry and Molecular Biology
Investigating the Role of the C-Terminal Domain in McsB, a Structurally Unique Tyrosine Kinase Found in Bacillus subtilis, James Graham
Department: Biochemistry and Molecular Biology