Senior Independent Study Theses from 2015
Virulence Modulation of Bordetella Pertussis via Inhibition of the Nicotinate Degradation Pathway, Lauren Buyan
Department: Biochemistry and Molecular Biology; Neuroscience
Elucidating the Degradation Pathway of Venlafaxine(Effexor), Naveeshini Nair Chandran
Department: Biochemistry and Molecular Biology
Cloning and Expression of the Novel Proteins in the Bacillus niacini Nicotinic Acid Degradation Pathway and an Initial Attempt to Characterize the NicAB Complex, Abigail K. Daniel
Department: Biochemistry and Molecular Biology
Mechanistic Insights into the Suppression of Mutations by the Yeast Peroxiredoxin Tsa1, Joseph B. David
Department: Biochemistry and Molecular Biology
Assessment and Comparison of Ornamental Plant Disease Resistance and Plant Growth as Effected by Microbial Inoculants, Tylar Fisk
Department: Biochemistry and Molecular Biology
Optimization and Characterization of Swellable Organically Modified Silica Particles for the Extraction of Volatile Fatty Acids, Alyssa Gilbert
Department: Biochemistry and Molecular Biology
Xerogel-Coated Sand for the Adsorption and Enzymatic Degradation of Micropollutants in Drinking Water Treatment Plants, Emily J. Gleason
Department: Biochemistry and Molecular Biology
A Molecular Analysis of Root-knot Nematode Nutrient Uptake, Allison B. Grenell
Department: Biochemistry and Molecular Biology
Investigating the Impact of Monofunctional and Bifunctional Electrophiles on Cellular Proteasome Activity, Brandon L. James
Department: Biochemistry and Molecular Biology
Exploring the Structural Basis for Negative Cooperativity in the Phosphagen Kinase Superfamily, Gentry Jarrett Kerwood
Department: Biochemistry and Molecular Biology
Modification of Saccharomyces cerevisiae oxidant defense proteins by the electrophiles N- ethylmaleimide and parthenolide, Karis Kosar
Department: Biochemistry and Molecular Biology
Inhibition and Kinetic Isotope Effect Studies to Further Characterize the Mechanism of Maleamate Amidohydrolase (NicF), Karan Malani
Department: Biochemistry and Molecular Biology
Cloning, Purification, and Analysis of an Aromatic Monooxygenase Protein Involved in the Production of Strain-Specific Phenazine Metabolites, Edmund W. Shi
Department: Biochemistry and Molecular Biology
Preliminary Investigation of Arginine Kinase in Caenorhabditis elegans, Dempsey J. Simonis
Department: Biochemistry and Molecular Biology
A Screen for S. cerevisiae Mutants Hypersensitive to the P. sojae effector PsAvh172, Matthew J. Sydor
Department: Biochemistry and Molecular Biology
Senior Independent Study Theses from 2014
Transcriptional Response to the Phytophthora Sojae Avh110 Effector Protein Using a Yeast Expression Study, Gabriel J. Abud
Department: Biochemistry and Molecular Biology
Investigating the Effects of Small Molecule Inhibitors of Potassium Channels on Mortality Rate and Urine Excretion in Female Aedes aegypti, Sheila O. Amoako
Department: Biochemistry and Molecular Biology
Evolution of Negative Cooperativity in Phosphagen Kinases, Manish Aryal
Department: Biochemistry and Molecular Biology
Electrophilic Modification of Methionine Sulfoxide Reductases - Mxr1 and Ykg9 from Baker's Yeast, Juliet Chepngeno
Department: Biochemistry and Molecular Biology
A Scientific Paradigm Shift from Reductionism to Holism: The Potential Relationship between Nicotinate Degradation and Virulence Modulation in Bordetella pertussis, Pailin Chiaranunt
Department: Biochemistry and Molecular Biology; Philosophy
Examining a Role for Thioredoxin in Protecting Against Protein Damage by Isothiocyanate-Containing Electrophiles, Sreyan Chowdhury
Department: Biochemistry and Molecular Biology
An Analysis of the Bioremediaiton of Venlafaxine, James B. Claybourne IV
Department: Biochemistry and Molecular Biology
LC-MS/MS Analysis of Fluoxetine and Serotonin-Related Compounds in Eisenia Fetida Living in Treated Soil, Maria Dawaher
Department: Biochemistry and Molecular Biology; Chemistry
Effect of Growth Selection on Adipogenic Gene Expression in Turkey Breast Muscle, Kory K. George
Department: Biochemistry and Molecular Biology
Molecular Biology of a Miracle: Conceptualization of Medicine Through the Amish-Religious Lens and Antimicrobial Properties of Burdock Burn Wound Treatment, Caroline H. Gormley
Department: Biochemistry and Molecular Biology; Religious Studies
An Investigation of the Inhibition of Phenazine Biosynthesis in Pseudomonas, Holly M. Jacobs
Department: Biochemistry and Molecular Biology
Assessment of the Biocontrol Activity of Mitsuaria Isolates Through Indole-3-acetic Acid Regulation and Plant Pathogen Inhibition, Christine M. Kasprisin
Department: Biochemistry and Molecular Biology
Elucidation of Bordetella bronchiseptica Maleamate Amidohydrolase (NicF) Substrate Specificity, Helena M. Kondow
Department: Biochemistry and Molecular Biology
Using Cultivation-Independent Methods to Investigate Venlafaxine Biodegradation, Zena Lapp
Department: Biochemistry and Molecular Biology
Exploring a Role for Thioredoxin in the Recognition of Electrophilic Modifications in Substrate Proteins, Matthew Naticchia
Department: Biochemistry and Molecular Biology
Developing Swellable Organically Modified Silica as a Drug Delivery System for Proteins, Austin Oberlin
Department: Biochemistry and Molecular Biology
Investigating the In Vitro Binding Interactions of Dbp6 and Two Potential Protein Cofactors in 60S Ribosomal Biogenesis, William P. Pender III
Department: Biochemistry and Molecular Biology
Identifying a Novel Host Target of the Pytophthora sojae RxLR Effector Protein PsAvh172, Matthew S. Reeder
Department: Biochemistry and Molecular Biology
Mechanistic Examination of the Mutator Phenotype in Saccharomyces cerevisiae Lacking the Peroxiredoxin Thioredoxin Peroxidase 1, Trevor J. Roston
Department: Biochemistry and Molecular Biology
Preliminary Investigations into the Essential Region of DEAD-Box Protein 6, Zachary BC Rotter
Department: Biochemistry and Molecular Biology
The Development of a Non-Surgical Sterilant for Dogs, Erica Skillman
Department: Biochemistry and Molecular Biology
Pertusiss, Pellagra, and Poverty: A Historical and Scientific Analysis of Whooping Cough's Associations with Poverty and Pellagra, and the Nicotinate Degradation Pathway in Bordetella Pertussis, Jacob Sprano
Department: Biochemistry and Molecular Biology; History
Developing an Effective Vaccine for Porcine Reproductive and Respiratory Virus (PRRSV), John M. Thompson
Department: Biochemistry and Molecular Biology
Disrupting Dimer Formation in the Baker’s Yeast Alkyl Hydroperoxide Reductase 1 (Ahp1), Susmit Tripathi
Department: Biochemistry and Molecular Biology
Senior Independent Study Theses from 2013
Characterization of Two Contiguous-Dimer Taurocyamine Kinases From the Parasitic Trematodes Schistosoma Japonicum and Clonorchis Sinensis, Brittany Begres
Department: Biochemistry and Molecular Biology
A Preliminary Analysis of the Differences in Cyclosporin a Resistance Between Amino Acid Residues P538 and P540 of the Hepatitis C Polymerase, Alexandra Kuzmishin
Department: Biochemistry and Molecular Biology
Protective Role of the Yeast Peroxiredoxin Tsa1 Against Electrophile-Mediated Stress, Andrew Lamade
Department: Biochemistry and Molecular Biology
Size Selective Dna Purification Using Swellable Organically Modified Silica, Brian Alexander Lupish
Department: Biochemistry and Molecular Biology
Shedding Light on the DEAD: Preliminary Investigation Into Dbp6, a DEAD-box Protein Required For Ribosome Assembly, Kari Martyniak
Department: Biochemistry and Molecular Biology
Investigating Cis-Elements of Microtubule-Associated Protein Tau's 3'-Untranslated Region, Daniel Montagna
Department: Biochemistry and Molecular Biology
Investigation of Functional Roles For Thioredoxins in Protecting Against Reversible Electrophile Induced Protein Damage in Saccharomyces Cerevisiae, Wesley J. Murphy
Department: Biochemistry and Molecular Biology
Characterization of a Creatine Kinase Enzyme From Cryptosporidium Muris, Paige Piper
Department: Biochemistry and Molecular Biology
Protein Cross-Linking As a Mechanism of Cytotoxicity For Bifunctional Electrophiles, Nikolai Radzinski
Department: Biochemistry and Molecular Biology
Assessing the Ability of Environmental Microbes to Catabolically Degrade the Antidepressant Venlafaxine (Effexor®), Kathryn Clare Sullivan
Department: Biochemistry and Molecular Biology
The Impact of Formate on the Physiology of Campylobacter jejuni, Michael T. Terribile
Department: Biochemistry and Molecular Biology; Neuroscience
Characterizing the Role of 2-Oh-Pca in P. Chlororaphis Pathogenesis, Abigail Toothman
Department: Biochemistry and Molecular Biology
Protein Drug Delivery Using Swellable Organically Modified Silica, Stephen Wanner
Department: Biochemistry and Molecular Biology
Senior Independent Study Theses from 2012
Glycogen Synthase Kinase-3 Regulates DNA Methylation Near Genes Implicated in Bipolar Disorder, Colleen Marie Bartman
Department: Biochemistry and Molecular Biology
Synergistic Effects of Triclosan and Triclocarban on the Physiology and Behavior of Fathead Minnows (Pimephales promelas), Sureni Beckford
Department: Chemistry; Biochemistry and Molecular Biology
Arginine Kinase of Myxococcus Xanthus Influences Development in a Manner Dependent on the Conditions of Development, Thomas Bohl
Department: Biochemistry and Molecular Biology
Influence of the Protein Cross-Linker Diethyl Acetylenedicarboxylate on 20S Core Particle Degradation of Candidates for the 26S Proteasome, TeQuion M. Brookins
Department: Biochemistry and Molecular Biology
Alterations in the Activity of the Yeast Peroxidase Tsa1 Upon Modification By Alkylating Agents, Haley A. Brown
Department: Biochemistry and Molecular Biology
Isolation of Bacterial Strains in Wastewater Sludge Capable of Degradation of Sertraline, Venlafaxine and Triclocarban, Jonathan Fox
Department: Biochemistry and Molecular Biology
Burdock Leaves: Cellular and Antimicrobial Effects in Burn Wound Treatment, Kelsie L. Herring
Department: Biochemistry and Molecular Biology
Evolutionary Study of the Phosphagen Kinase Enzyme Family Probing Substrate Specificity and Cooperativity in Software Derived Ancestral Proteins, Eric Johnson
Department: Biochemistry and Molecular Biology
Investigation of the Potential Role of 6-Hydroxynicotinate-3-Monooxygenase in the Modulation of Virulence in Bordetella Pertussis, Samantha Justice
Department: Biochemistry and Molecular Biology
Progress Towards the Characterization of a Novel Substrate-Analog Inhibitor of Udp-3-O-(R-3-Hydroxymyristoyl)-N-Acetylglucosamine Deacetylase, Emily Christine Linville
Department: Biochemistry and Molecular Biology
Investigation Into the Catalytic Mechanism of Maleamate Amidohydrolase (NicF) from Bordetella Bronchiseptica RB50, Jeffrey Noel
Department: Biochemistry and Molecular Biology
Generation of Thioredoxin 1 and Thioredoxin 2 Mutants in S. Cerevisiae and a Philosophical Investigation of the Ethical Implications of Human Genetic Engineering, Logan D. Pry
Department: Biochemistry and Molecular Biology; Philosophy
Entrapment and Determination of Lipase Embedded in Swellable Organosilica, Modeling Particle Aggregation and Aging of Colloidal Sol-Gels, Kemar Reid
Department: Biochemistry and Molecular Biology
Probing the Role Cysteine-150 in Maleamate Amidohydrolase (NicF) Catalysis From Bordetella Bronchiseptica RB50 By Site-Directed Mutagenesis, Nicholas Spittle
Department: Biochemistry and Molecular Biology
Identification and Characterization of HAP1, a YAP1 Homologue, in the Fungus Histoplasma Capsulatum, Blain Tesfaye Fente
Department: Biochemistry and Molecular Biology
Computational Profiling and Identification of the 3' Untranslated Region Within Paramecium Tetraurela, Tristan Vrolijk
Department: Biochemistry and Molecular Biology; Computer Science
Mapping Polyprotein Cleavage Sites in the R78 Region of Maize Chlorotic Dwarf Virus, Yujing Zhao
Department: Biochemistry and Molecular Biology
Senior Independent Study Theses from 2011
Investigating the Localization and Function of the Prodomain of Neuronal Interleukin-16 on N1E-115 Cells, Cassondra Agozzino
Department: Biochemistry and Molecular Biology
Influence of Proteasome Inhibition on the Baker's Yeast Transcription Factor Yap1p Following Its Activation By Organic Electrophiles, Omar Atassi
Department: Biochemistry and Molecular Biology
Investigation of a Putative Arginine Kinase From Desulfobacterium Autotrophicum: Evolutionary Implications For the Bacterial Arginine Kinases, Christopher DeMoll
Department: Biochemistry and Molecular Biology
Investigating the Role of Threonine-58 in Creatine Kinase Activity and Active Site Communication, Dmytri Eck
Department: Biochemistry and Molecular Biology
Developing a Mechanistic Proposal For 2,5-Dihydroxypyridine-5,6-Dioxygenase (NicX) from Bordetella Bronchiseptica, Matthew Henke
Department: Biochemistry and Molecular Biology
A Study of the Structure/Function Relationship of NicF in the Bordetella Bronshiseptica Nicotinic Acid Degradation Pathway, Roger Klein
Department: Biochemistry and Molecular Biology
Method Development For Quantitative Analysis of Prostanoids and Isoprostanes in Human Serum to Investigate the Molecular Basis of Aspirin Resistance, Mary Kate Lockhart
Department: Biochemistry and Molecular Biology
Organosilica-Polymer Composit Materials For Capture and Release of DNA for Forensic Application, Laszio Marcze
Department: Biochemistry and Molecular Biology
Thermodynamic and Infrared Spectroscopic Study of the Excited State Intramolecular Charge Transfer of 4-Aminobenzoic Acid and 4-Dimethylaminobenzoic Acid, Zachery Matesich
Department: Biochemistry and Molecular Biology
Analysis and Characterization of Siphonosoma Cumanense HTK: Evolutionary Implications, Robert Mayer Jr
Department: Biochemistry and Molecular Biology
The Characterization of a Hybrid Histidine Kinase in the Pathogenic Dimorphic Fungus Histoplasma Capsulatum, Mary Rebecca Moreci
Department: Biochemistry and Molecular Biology
An Investigation of the Ability of Pseudomonas Fluorescens to Degrade the Antidepressent Sertraline (Zoloft®), Brad Palanski
Department: Biochemistry and Molecular Biology
Identification of Genes That Provide Cellular Protection Against a Thiol Cross-Linking Agent in Saccharomyces Cerevisiae, Chelsea Stamm
Department: Biochemistry and Molecular Biology
Characterization of Siderophore Transporters Abc1 and Mfs1 in Histoplasma Capsulatum Pathology, Emily Weitz
Department: Biochemistry and Molecular Biology
Evidence of Subfunctionalization in the Calcineurin Gene Family in Paramecium Tetraurelia, Jordan Welker
Department: Biochemistry and Molecular Biology
Senior Independent Study Theses from 2010
Viral Pathogen Removal From Water Using Swellable Organically Modified Silica, Emily J. Barth
Department: Biochemistry and Molecular Biology
Differential Gene Expression of H. Bacteriophora TTO1 in Response to Heat Stress, Marc Christian
Department: Biochemistry and Molecular Biology; Mathematics
Identifying Genes Required For Growth in Histoplasma Capsulatum Under Osmotic Stress Conditions, Angela Grass
Department: Biochemistry and Molecular Biology
Chemical Analysis of Materials Used to Create the Paint Found on the College of Wooster's Egyptian Coffin, Kimberly Anne Krall
Department: Biochemistry and Molecular Biology
Capacity For Microbial Biomass to Be Used in Biological Control to Manage Plant Pathogen Growth: Advancement of Pseudomonas Flourescens Strain Wayne1R As a Biocontrol Agent Through Identification of Novel Biocontrol Genes, Seth A. Maurer
Department: Biochemistry and Molecular Biology
Expression and Characterization of Phytophthora Sojae Phosphagen Kinases, Allyson Kaitlin Palmer
Department: Biochemistry and Molecular Biology
Nad Catabolism: Identification of a 6-Hydroxynicotinate 3-Monooxygenase in Bordetella Bronchiseptica, Ryan Wilson Story
Department: Biochemistry and Molecular Biology
Effects of Neuregulin-1 on Long Term Potentiation in Cerebellar Granule Cells in Vitro, Andrew Trembath
Department: Biochemistry and Molecular Biology
Senior Independent Study Theses from 2009
Investigating the Use of Oral Creatine Supplementation As a Means of Treatment For the Symptoms of Fibromyalgia Syndrome, Valerie Marie Andrus
Department: Biochemistry and Molecular Biology
Using GFP Fusion Proteins to Screen For the Subcellular Localization of Phytophthora Infestans RXLR Effectors in Host Cells, Samantha Jo Armintrout
Department: Biochemistry and Molecular Biology
Investigating the Role of the IQ67 Domain in the Interaction Between SUN and Calmodulin: An Endeavor Into the Treacherous World of Protein Expression Via Escherichia Coli, Stephanie Louise Edmisson
Department: Biochemistry and Molecular Biology
Microbial Degradation of Triclosan Within Wastewater Treatment Plants, Sarah Gollwitzer
Department: Biochemistry and Molecular Biology
Characterizing the Role and Function of Two Hybrid Histidine Kinases in Histoplasma Capsulatum, Daniel W. Grangaard
Department: Biochemistry and Molecular Biology
DNA Geometry and Its Biological Significance, Lorna Johnston
Department: Biochemistry and Molecular Biology; Mathematics
Using Computational Genomics to Develop a General Gene Model For the Plant Pathogen Phytophthora Infestans, Michael Kwan
Department: Biochemistry and Molecular Biology