Senior Independent Study Theses from 2023
Exploring the Binding Multiplicity, Mode of Inhibition and Communication Between NADH Binding Sites on 6- Hydroxynicotinate 3-monooxygenase (NicC), Eric Senanu Adadevoh Mr.
Department: Biochemistry and Molecular Biology
Porphyrin Based Photosensitizing Agents: Comparative Study On The Effects Of TPP-sesamol and TPP-zingerone On Yeast Cells, Edwina Akonor
Department: Biochemistry and Molecular Biology
Measurement & Analysis of Pesticide Biotransformation Products in Ohio Precipitation Samples, Lily Anderson
Department: Biochemistry and Molecular Biology
Interrogation of a Conserved Overlap Between Cofactor and Substrate Binding Domains to Facilitate Crosstalk-Induced Conformational Changes in Class A Flavin Monooxygenases: A Case Study of 6-Hydroxynicotinate-3-Monooxygenase, Sam L. Belsky
Department: Biochemistry and Molecular Biology
Analysis of P. aeruginosa Antibiotic Resistance Development at Variable Ciprofloxacin Growth Concentrations In Vitro and In Vivo Using C. elegans Host, Daniel William Bohl
Department: Biochemistry and Molecular Biology
Metabolomics of iPSC-derived Cardiomyocyte Secretions for Biomarker Discovery in Leigh Syndrome, Amber J. Dinchman
Department: Biochemistry and Molecular Biology
Metabolomics of iPSC-Derived Cardiomyocyte Secretions for Biomarker Discovery in Leigh Syndrome, Amber J. Dinchman
Department: Biochemistry and Molecular Biology
Exploring Novel Redox Partners and Properties of the Thioredoxin Reductase Trr1 from Saccharomyces cerevisiae, To Uyen Do
Department: Biochemistry and Molecular Biology
Polycyclic Aromatic Hydrocarbon (PAH) Pollution Analysis and Ameiurus Nebulosus Gene Expression Can Predict Environmental Health, Naomi Fernandes
Department: Biochemistry and Molecular Biology
Liver Tumors in Beckwith Wiedemann Syndrome: Can Alpha-Fetoprotein Levels Distinguish Benign from Malignant Tumors?, Sena Houessou-Adin
Department: Biochemistry and Molecular Biology
Liver Tumors in Beckwith Wiedemann Syndrome: Can Alpha-Fetoprotein Levels Distinguish Benign from Malignant Tumors?, Sena Disewari Houessou-Adin
Department: Biochemistry and Molecular Biology
Creation of Dimeric Perkinsus Marinus Creatine Kinase Through Site-Directed Mutagenesis: Insight into Phosphagen Kinase Quaternary Structure Evolution, Kyungjoo Kim
Department: Biochemistry and Molecular Biology
Investigation Of SI And PC1 Bacteriophages' Putative Genomic Identities And Infection Methods On Phage Resistant Pseudomonas Chloraphis, May M. Le
Department: Biochemistry and Molecular Biology; Biology
Metabolomics to Predict the Onset of Cardiomyopathy in Patients with Propionic Acidemia, Riley Thomas McErlean
Department: Biochemistry and Molecular Biology
A Polynucleotide Biosensor for the Prostate Cancer Specific Biomarker PCA3, Christopher Andrew Meyer
Department: Biochemistry and Molecular Biology
A Polynucleotide Biosensor for the Prostate Cancer Specific Biomarker PCA3, Christopher Andrew Meyer
Department: Biochemistry and Molecular Biology
A Polynucleotide Biosensor for the Prostate Cancer Specific Biomarker PCA3, Jessica Krystal Meyer
Department: Biochemistry and Molecular Biology
Structural Stability of Bovine Serum Albumin upon Adsorption to SOMS Measured by FT-IR, Kylie M. Schmitz
Department: Biochemistry and Molecular Biology
Toward a Comprehensive Framework for Investigating Copper Dyshomeostasis: The Role of His-Tag Modularity and Alternative Expression Systems in Evaluating Dopamine β-Hydroxylase, Zoë Lee Semersky
Department: Biochemistry and Molecular Biology
Immobilization of Transferrin in Swellable Organically Modified Silica for Remediation of Heavy Metal Ions, Shiropa Shahreen
Department: Biochemistry and Molecular Biology
Investigation of Splicing Changes in dNab2 Knockdown Drosophila Neurons, Katherine J. Shelmidine
Department: Biochemistry and Molecular Biology
Conservation of Dynamic Modularity in Biological Network Modeling: Modular Boolean Model of Cell Cycle Regulation in Saccharomyces cerevisiae, Caitlin Strassburg
Department: Biochemistry and Molecular Biology; Mathematics
Identifying Potential Redox Partners of the Yeast Mitochondrial Thioredoxin, Griffin G. Suppa
Department: Biochemistry and Molecular Biology
Cytochrome p450 1A Oxidation of Pollutant Benzo(a)pyrene's Genetic Effect on Ameiurus nebulosus’ p53 and MDM2 Genomic Region, Breanna Watkins
Department: Biochemistry and Molecular Biology
Determining The Crystal Structure of The Staphylococcus Aureus MurG Enzyme, Patrick Thomas Wood
Department: Biochemistry and Molecular Biology
Identification of a Putative Binding Mechanism for the Reducing Substrate of 6-Hydroxynicotinate 3-Monooxygenase, Takoda T. Zuehlke
Department: Biochemistry and Molecular Biology
Senior Independent Study Theses from 2022
Phenotypic Rescue Of Key Social Behaviors In M. Xanthus By The Desulfotalea Psychrophila Arginine Kinase, Nathaniel J. Arday
Department: Biochemistry and Molecular Biology
Role Of Tight Binding In Negative Cooperativity In The Dimeric Mitochondrial Taurocyamine Kinase From Arenicola Brasiliensis, Robert M. Beal
Department: Biochemistry and Molecular Biology
Identification And Detection Of Biomarkers Of Dilated Cardiomyopathy In A Cohort Of Amish Patients With Propionic Acidemia Using High Resolution Mass Spectrometry, Alexa Nicole Bencic
Department: Biochemistry and Molecular Biology
To Clean Or Not To Clean: Exploring The Ability Of Biocidal Compounds To Induce Physiological Changes In Bacteria That May Increase The Spread Of Antibiotic Resistance Genes, Kayla R. Bertholf
Department: Biochemistry and Molecular Biology
Boolean Model Of Mesenchymal Cell'S Resistance To Chromosomal Senescence, Arnav Bhatnagar
Department: Biochemistry and Molecular Biology
Synthesis, Characterization, And Biological Activity Of Silver (I) Fatty Acid Complexes Against Candida Albicans, Macy Faith Bischoff
Department: Biochemistry and Molecular Biology
The Seven Deadly Pathways: A Boolean Model Of Yeast Apoptosis In Response To Reactive Oxygen Species, DNA Damage, And Salt, Andrea Brown
Department: Biochemistry and Molecular Biology
Molecular Recognition Within The Es Complex: A Mechanistic Investigation To Discern How 6-Hydroxynicotinate-3-Monooxygenase (Nicc) Distinguishes Between Substrate Analogues When Enhancing Its Rate Of Nadh Oxidation, Joel K. Brown
Department: Biochemistry and Molecular Biology
“It’S Not Just A Phage, Mom”: An Examination Of Antibiotic Resistance In Pseudomonas Aeruginosa In Response To Bacteriophage Treatment, Kirsten N. Buchan
Department: Biochemistry and Molecular Biology
Effects Of Xenobiotic Pollution On Histopathological Alterations And Cyp1A Expression On Brown Bullhead (Ameiurus Nebulosus) In Wooster, OH, Madison A. Crucs
Department: Biochemistry and Molecular Biology
The Virome Of Aedes Japonicus And Culex Spp., Collected In Wooster, Oh, Usa, Alexander R. DeLong
Department: Biochemistry and Molecular Biology
Biochemical Analysis Of The Myxococcus Fulvus 124B02 Arginine Kinase, Krista L. English
Department: Biochemistry and Molecular Biology
Analysis Of The Antimicrobial Activity Of The Novel Chemotherapeutic Drug, Tpp1, Against Pseudomonas Aeruginosa And The Hydrogel Delivery Of Water-Soluble Antimicrobial Compounds, Alex Gasper
Department: Biochemistry and Molecular Biology
Advances In Characterizing The Gene-Encoded Subunits That Compose The Nicotinate Dehydrogenase And 6-Hydroxynicotinate Dehydrogenase Enzyme Complexes Within The Bacillus Niacini Nicotinic Acid Degradation Pathway, Emilee R. Haines
Department: Biochemistry and Molecular Biology
Investigating Substrate Specificity For 6-Hydroxynicotinate 3- Monooxygenase (Nicc) With Alternative Substrates: Consequences To Catalysis Of Replacing Or Removing The Ring Nitrogen, May Zin Hlaing
Department: Biochemistry and Molecular Biology
Characterization Of A Potential Novel Redox Partner In S. Cerevisiae Mitochondrial Disulfide Relay System And In Silico Elucidating Its Essentiality, Thinh Huynh
Department: Biochemistry and Molecular Biology
The Influence Of Silver (I) Carboxylate Ligand Structure On Antimicrobial Activity In Pseudomonas Aeruginosa, Kylie E. Keller
Department: Biochemistry and Molecular Biology
Synthesis, Characterization, And Antimicrobial Activity Of Folic Acid And Glutamic Acid Derived Silver (I) Compounds Against Pseudomonas Aeruginosa, Benjamin James Kennedy
Department: Biochemistry and Molecular Biology
Advances In The Elucidation Of The Nicotinic Acid Degradation Pathway In Bacillus Niacini: Proof Of Formation Of The Trihydroxypyridine Intermediate And The Characterization Of An Fmn-Dependent Flavoprotein Of Unknown Function, Sai Kwan Khal
Department: Biochemistry and Molecular Biology
Examining The Role Of Arginine Kinase In The Social And Physiological Processes Of Myxococcus Xanthus, Lillian R. MacLean
Department: Biochemistry and Molecular Biology
Following The Lead: Impact Of Soil Amendments On Lead Toxicity To Tomato, Alicia McElwee
Department: Biochemistry and Molecular Biology
The Effect Of Adipokinetic Hormone (AKH) On Fecundity Of Aedes Aegypti Mosquitoes., A'Janay C. Nicholson
Department: Biochemistry and Molecular Biology
Examining The Effects Of Angiotensin I-Converting Enzyme On The Fecundity Of Female Aedes Aegypti Mosquitoes, Daphne Lynn Pate
Department: Biochemistry and Molecular Biology
Allelochemical In Situ Evaluation Of A Swellable Organically Modified Silica Based Sampler Using Lc-Ms/Qtof, Damien M. Sausville
Department: Biochemistry and Molecular Biology
Investigating Whether The Rna Binding Protein Nab2 Regulates Tau Mrna Levels In A Fly Model Of Neurodegeneration, Emma Grace Schwinne
Department: Biochemistry and Molecular Biology
Boolean Modeling Of The Interactions Between Inflammation, Hypoxia, And The Epithelial-Mesenchymal Transition (Emt), Ian Zonfa
Department: Biochemistry and Molecular Biology
Characterization Of The Natural Antibiotic Activity Of Pseudomonas Environmental Isolates, Harrison Zwolshen
Department: Biochemistry and Molecular Biology
Senior Independent Study Theses from 2021
The Female Perspective: An Investigation Into How the Reconstruction and Efficacy of a Gynecological Fertility Recipe Unveils Female Voice in the Hippocratic Corpus, Randa Elie Abboud
Department: Biochemistry and Molecular Biology; Classical Studies; History
Maternal and Infant Factors That Influence Infant Microbiome Composition and Microbial Fucose Utilization, Grace E. Adkins
Department: Biochemistry and Molecular Biology
Investigating the Effects of the Phone a STEM Professional Assignment on STEM Students’ Sense of Belonging, Career Confidence, and Career Awareness, Kyla M. Babics
Department: Biochemistry and Molecular Biology
Simulating Mammalian Liver Homeostasis and the Impact of Senescence, Stuart Ryan Ball
Department: Biochemistry and Molecular Biology
Reconstitution of Hydroxylation Activity of Recombinant NDH and 6-HDH Complexes from Bacillus niacini, Luke Borgelt
Department: Biochemistry and Molecular Biology
Searching for Novel Redox Partners of the Mitochondrial Protein Erv1, Camryn A. Bragg
Department: Biochemistry and Molecular Biology
Investigation of the Metabolic Role of Triosephosphate Isomerase (TPI) in the Physiological function of Myxococcus xanthus, Sienna F. Carr
Department: Biochemistry and Molecular Biology
Elucidating Phosphagen Kinase Evolution through the Identification of Substrate Specific Arginine Kinases and Taurocyamine Kinase within Platyhelminthes, Emmalee Cooke
Department: Biochemistry and Molecular Biology
Investigating the Efficacy of RNAi for Use in the Study of Caenorhabditis elegans Arginine Kinase, Evan Thomas Faxon
Department: Biochemistry and Molecular Biology
Establishing a Functional Heterologous Expression System for Bacillus niacini Nicotinate Dehydrogenase and 6-Hydroxynicotinate Dehydrogenase Using Escherichia coli, Daniel T. Fleming
Department: Biochemistry and Molecular Biology
Using a Protein Cross-Linker to Confirm Protein Disulfide Isomerase Interactions and Impact on Downstream Processes, Wilson M. Freije
Department: Biochemistry and Molecular Biology
Tentative Detection of Phosphoarginine by LC-MS in M. xanthus, Asvin Gireesh
Department: Biochemistry and Molecular Biology
Purification and Crystallization of MurG: Towards Structural Characterization of a Ubiquitous Antibiotic Target, Peter E. Greenwood Jr
Department: Biochemistry and Molecular Biology
A Boolean Model of Crosstalk Between Senescence and Epithelial to Mesenchymal Transition, Marlayna Harris
Department: Biochemistry and Molecular Biology
Homology Modeling and Protein-Ligand Structural Analysis of the Bacillus niacini NicAB Protein Complex, Wenhao Hu
Department: Biochemistry and Molecular Biology
Layer up: An investigation of yeast flocculation in the context of genetic, environmental, and cell wall composition effectors, Brieanna Jarrell
Department: Biochemistry and Molecular Biology
Polymicrobial Competition: Bacteria and Fungi Compete Using a Unique Toxin Secreted Through the Type VI Secretion System, Olivia Johnson
Department: Biochemistry and Molecular Biology
An Examination of Antibiotic Resistance Genes in Pseudomonas chlororaphis in Response to Bacteriophage Therapy, Eric Kraus
Department: Biochemistry and Molecular Biology
Evidence of Negative Cooperativity in Cytosolic Taurocyamine Kinase from Arenicola brasiliensis and its Implication in the Evolution of the Phosphagen Kinase Family, Mingyuan "Merlin" Li
Department: Biochemistry and Molecular Biology
Deciphering the “Logic Puzzle” of Traditional Chinese Herbal Medicine: Investigating Cooperative Protective Effects of Artemisinin and Hyperoside Against Oxidative Damage in Saccharomyces cerevisiae, Kejun Liu
Department: Biochemistry and Molecular Biology
Phenotypic and Biochemical Analysis of Active Site Variation in Thioredoxin: A Conserved Oxidant Defense Protein Responsible for Disulfide Bond Reduction in Cells, Eran N. Maina
Department: Biochemistry and Molecular Biology
Elucidating the Biodegradative Pathway of Nicotinic acid by Bacillus Niacini: Defining the Biochemical Action of Bn DUF, Connor Thomas Mangan
Department: Biochemistry and Molecular Biology
Host Domination: Characterizing Pseudomonas chlororaphis Bacteriophage’s Host Range and Binding Receptors, Marissa E. Norgrove
Department: Biochemistry and Molecular Biology
Effect of Adipokinetic Hormone on Mating Receptivity of Aedes aegypti Females, Dhwani Parsana
Department: Biochemistry and Molecular Biology; Neuroscience
Investigating the Selective Advantages and Microenvironmental Requirements of Cellular Clustering Utilizing an Agent-Based Model of Yeast Flocculation, Alyssa N. Ramirez
Department: Biochemistry and Molecular Biology
Characterization of Substrate Promiscuity for 6-Hydroxynicotinate 3-Monooxygenase: A Transient Kinetic Investigation of the Decarboxylative-Hydroxylation of 5-Chloro-6-Hydroxynicotinic Acid, Jack Charles Redick
Department: Biochemistry and Molecular Biology
Stem Cell Research from 1990s – Present: The Development of iPSCs as a Response to Ethical Dilemma Surrounding Extraction of hESCs and Elucidating the Effect of Mechano-sensitivity during the First Differentiation Event of ESCs using Boolean Modeling., Hikmet A. Sherief
Department: Biochemistry and Molecular Biology; History
Impact of Active Site Motif Mutations on Yeast Thioredoxin 2 Activity, Shayna L. Vicker
Department: Biochemistry and Molecular Biology
Investigating the Role of cAMP in the Sleep Phenotype of the Drosophila Fragile X Syndrome Model, Miura Wiley
Department: Biochemistry and Molecular Biology
Senior Independent Study Theses from 2020
Venom Self-Degradation: Active Peptide Breakdown by A. compressa Neprilysin to Facilitate Hypokinesia, James M. Alltop
Department: Biochemistry and Molecular Biology
Impact of CXXC Motif Variation on the Function of the Yeast Thioredoxin Trx2, Morgan Bailey
Department: Biochemistry and Molecular Biology
Analysis of Salmonella and Listeria Localization in a Hydroponic System and the Effects of pH Reduction on Pathogenic Growth, Michelle Biksey
Department: Biochemistry and Molecular Biology
Seminal Fluid-Derived Adipokinetic Hormone (sfAKH) Influences Mating Behavior in Female Aedes aegypti with Observations on Accessory Reproductive Glands, Gemma Briggs
Department: Biochemistry and Molecular Biology; Neuroscience
Investigation of Phytophthora sojae’s RxLR effectors on the MAPK pathway in Saccharomyces cerevisiae, Michelle Chang
Department: Biochemistry and Molecular Biology
Zombie Cockroaches: Emerald Jewel Wasp Venom-Derived Neuropeptide Tachykinin Modulates Neuronal Cells of the American Cockroach, Spencer Michael Coffman
Department: Biochemistry and Molecular Biology
Impact of Various Degradation Pathways on Ribonucleotide Reductase Inhibitor Hug1 Stability in Saccharomyces Cerevisiae, Jason N. Constable
Department: Biochemistry and Molecular Biology
Analysis of Bacteria - Host Interactions between Caenorhabditis Elegans and Unexplored Bacteria, Harrison G. Davenport
Department: Biochemistry and Molecular Biology
Toxicity Analysis of OGT Inhibitor Et-OSMI-2 Against Strains of E. coli and Pseudomonas, Craig Deng
Department: Biochemistry and Molecular Biology
Differential Expression Analysis of the Nic Cluster and Attempts at Characterizing the Nicab Complexes in the Novel Nicotinic Acid Degradation Pathway of Bacillus Niacini, Anh Dinh
Department: Biochemistry and Molecular Biology
Impact of Tsa1 Subcellular Localization on its Biological Function, Daniel Dorman
Department: Biochemistry and Molecular Biology
Barely Scratching the Surface: Examining the Relationship between Carotenoid Pigment and Immunity of Betta splendens with Bco1, Samantha B. Draves
Department: Biochemistry and Molecular Biology
Wash Your Hands, You Filthy Animals! An Exploration of the Presence of Antibiotic Resistance Genes in Non-Clinical Settings, Ana R. Fairbanks-Mahnke
Department: Biochemistry and Molecular Biology
Using the Protein Cross-Linker Divinyl Sulfone to Identify the Putative Client Proteins of Protein Disulfide Isomerases and Its Effects on ER Homeostasis, Benjamin Freije
Department: Biochemistry and Molecular Biology
Caenorhabditis elegans' Use of Apoptosis in the Immune Response to Pseudomonas Bacterial Infections, Daniel Gail
Department: Biochemistry and Molecular Biology
No Need to Stress: The Effects of Protandim Supplementation on Counteracting Oxidative Stress via the Nrf2 Pathway, Kelsey Taylor Hall
Department: Biochemistry and Molecular Biology; Neuroscience
Mosquitoes Bloody Suck!: Identifying Potential Vectors and Non-Human Hosts of Mosquito-Borne Pathogens in Alajuela, Costa Rica, Emma R. Hambright
Department: Biochemistry and Molecular Biology; Neuroscience
Progress in Characterizing a Novel Root Exudate: Differential gene expression of Bacillus niacini DSM 2993 in Response to Nicotinic Acid through RNA-seq, Noah S. Helton
Department: Biochemistry and Molecular Biology