Abstract
The microbiome is very important in regulating host physiology, metabolism, and immune function. In C. elegans, the microbiome influences phenotypic traits of the host by regulating signaling pathways and stress resistance. In this study, we analyzed how the colonization of the microbiome by two bacterial strains, JUb134 and JUb19, impacted stress resistance in C. elegans. To assess strain-specific effects and phenotypic changes, oxidative and heat stress assays were conducted. The results of this study show that JUb134 fed worms had the highest survival compared to JUb19 fed worms in both stress conditions. These findings indicate that a bacterial diet can influence stress resistance in C. elegans. Also, it is possible that the presence of one strain can activate stress response pathways differently in C. elegans. Future studies could analyze how the stress response pathways are activated differently when faced with environmental stressors. Understanding these interactions can further clarify how bacterial colonization of the microbiome contributes to stress resistance.
Advisor
Strand, Stephanie
Department
Biology
Recommended Citation
Peddapally, Renee R., "Microbiome-Mediated Stress Resistance: Effects of JUb134 and JUb19 in Caenorhabditis elegans" (2026). Senior Independent Study Theses. Paper 13547.
https://openworks.wooster.edu/independentstudy/13547
Disciplines
Medicine and Health Sciences
Publication Date
2026
Degree Granted
Bachelor of Arts
Document Type
Senior Independent Study Thesis
© Copyright 2026 Renee R. Peddapally