Previous research has indicated that depression impairs cognitive function, especially learning and memory. Antidepressants have been to found to reverse the negative effects of depression to help improve learning and memory. When using an animal model, chronic mild stress (CMS) is the best way to replicate depression in animals. This research focused specifically on the effects of chronic mild stress and duloxetine on learning and memory. There were four experimental groups: stress with duloxetine, stress without duloxetine, duloxetine without stress, and a control. For the appropriate treatment groups the rats were exposed to various CMS for 42 days and duloxetine (10mg/kg) for 21 days. Learning and memory was tested using the Morris water maze (MWM). A significant interaction between stress and duloxetine was found. This suggested duloxetine might be reversing the damage done by CMS to improve learning and memory.


Stavnezer, Amy Jo




Cognitive Neuroscience

Publication Date


Degree Granted

Bachelor of Arts

Document Type

Senior Independent Study Thesis



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