Alzheimer’s Disease is a neurodegenerative disorder that causes abnormal processes in the brain leading to behavioral changes such as progressive memory loss, reduced inhibition, and decreased motor functions. Previous research efforts have explored treatment options such as behavioral therapies or altered diets. The current study aims to determine the effectiveness of an antioxidant supplement, Protandim, on AD in a mouse model. It was hypothesized that supplementation of Protandim to transgenic mice with 5xFAD would significantly improve their memory and learning in behavioral tests such as the Morris water maze and open field. Although the current study evaluated potential behavioral effects, a hypothesized route of change in the brain occurred in the transcription factor nuclear factor E2-related factor 2 (Nrf2) and its associated pathway. Additionally, shock avoidance learning was assessed in the passive avoidance test. There were no significant effects of Protandim or the AD genotype in this study. Although Protandim was not found to induce changes in the behavior of the mice in this study, perhaps adjustments in the length of time or start time of giving the supplement. Changes such as these could potentially result in the positive effects in mice that Protandim is suggested to have on humans without AD.
Stavnezer, Amy Jo
Grossmann, Jennifer, "The Effect of the Antioxidant Supplement, Protandim, on a Mouse Model of Alzheimer’s Disease" (2020). Senior Independent Study Theses. Paper 9087.
Behavioral Neurobiology | Cognitive Neuroscience
Bachelor of Arts
Senior Independent Study Thesis
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