The full text of Senior Independent Study Theses submitted during and after 2012 are available to download only by College of Wooster users. Unless listed as an exemplar, all other theses are restricted.

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Senior Independent Study Theses from 2018

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Assessing the Subcellular Localization of Phytophthora sojae plant pathogen RXLR Effectors in Saccharomyces cerevisiae., Titas K. Bera
Department: Biochemistry and Molecular Biology

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Attempt at Expression of a Functional Recombinant Nicotinate Dehydrogenase from Bacillus niacini, Nathan M. Brownstein
Department: Biochemistry and Molecular Biology

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Probing the Activity of [(n6-p-cymene)RuCl2(P(R)3)] Complexes for the Metal-Catalyzed Oxidative Coupling of Alcohols and Amines, Brady Bunnell
Department: Chemistry

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Everyday Acts of Amish Resistance: Contextualizing Patterns of Antimicrobial Susceptibility in a Small-Scale Agricultural Setting, Geoffrey Carney-Knisely
Department: Biochemistry and Molecular Biology; Sociology and Anthropology

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Using A Boolean Model to Identify Requirements for Successful Yamanaka Reprogramming, Campbell Elliott
Department: Biochemistry and Molecular Biology

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Elucidating the Physiological Role of a Putative Arginine Kinase in Myxococcus xanthus Utilizing Homologous Recombinants, Zachary J. Engfer
Department: Biochemistry and Molecular Biology

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An Evolutionary Myx-up: Characterization of Bacterial Arginine Kinases in Species from the Order Myxococcales, Lindsay J. Fannin
Department: Biochemistry and Molecular Biology

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Niacini, Now You Don’t: The Catabolism of Nicotinic Acid and Nicotine and the Role of a Putative Monooxygenase Enzyme in Bacillus niacini, Sydney R. Fine
Department: Biochemistry and Molecular Biology

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Adsorption of Biomolecules by Porous Organosilica, Amy L. Graham
Department: Biochemistry and Molecular Biology

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Investigation of Carminic Acid Photodegradation: Separation, Analysis, and Characterization of Photoproducts, Margaret F. Heller
Department: Chemistry

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Chasing the Light: Determining a Consistent Method of Device Fabrication for Single-Layered Organic Light Emitting Diodes, Austinjit S. Khara
Department: Chemistry

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Understanding Gene Expression Alterations Following Sleep Deprivation, Ksenia J. Klue
Department: Biochemistry and Molecular Biology

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Evaluation of Organosilica Sorbent Media as an Adsorbent for the Removal of Perfluoroalkyl Substances from Contaminated Groundwater, Michaela Lawrence
Department: Chemistry

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It's Ground Breaking: Development of Soil Insertion Passive Sampler for Chemically Informed Crop Management, Katherine J. Longo
Department: Biochemistry and Molecular Biology

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Investigating the Role of Phytophthora sojae Effector Protein PsAvr3c in the Endoplasmic Reticulum UPR Defense Pathway, Katherine Lyden
Department: Biochemistry and Molecular Biology

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Betta Understanding: Characterization and Sequencing of Genes Putatively Responsible for Red Phenotypic Variation in Betta splendens, Maria Mullin
Department: Biochemistry and Molecular Biology

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Elucidating the Mechanism of 6-Hydroxynicotinate 3-Monooxygenase, an Enzyme Involved in the Aerobic Degradation of Nicotinate, Kent Nakamoto
Department: Chemistry

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Characterization of a Putative TplE Protein in Pseudomonas chlororaphis 14B11, Ankitha Nanjaraj
Department: Biochemistry and Molecular Biology

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Evaluation of Fluorinated Swellable Organically-Modified Silica for the Adsorption of Perfluoroalkyl Substances, Huan Khoa Nguyen
Department: Chemistry

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Modeling the Effects of P14 and P53 on Common Oncogenic Pathways, Elizabeth Obi
Department: Biochemistry and Molecular Biology

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Investigating the Indirect Photolysis of Warfarin and Nitrates via Hydroxyl Radical Photochemistry, Matthew J. Pech
Department: Chemistry

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The Making of a Modern Fragrance: Extending Fragrance Release From Swellable Organosilica Using Nonvolatile Co-Absorbates, Evon Petek
Department: Chemistry

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Impact of Altered Redox Homeostasis and Ribonucleotide Reductase Activity on Mutation Rates in S. cerevisiae, Matthew Pleshinger
Department: Biochemistry and Molecular Biology

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An Attempt to Sequence Genes Tyrp1a and Mc1r in Black and Red Phenotype Betta splendens, Bryan Robb
Department: Biochemistry and Molecular Biology

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Help! Help! I am Being Repressed! : An In-Depth Analysis of the IclR and its In-Vitro Oligimerization, Derek B. Schwarz
Department: Biochemistry and Molecular Biology

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Leaf Me Alone: Investigating The Effect of Phenazines On The Systemic Resistance of Arabidopsis thaliana, Olivia A. Seale
Department: Biochemistry and Molecular Biology

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Investigation of dNab2 Loss in D. Melanogaster Causing Changes in Sleep/ Circadian Rhythms, Kiandra Smith
Department: Biochemistry and Molecular Biology

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An Investigation into the Lambert-Beer Law in Incoherent Broad-Band Cavity-Enhanced Absorption Spectroscopy, Zane R. Thornburg
Department: Chemistry; Physics

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Phenotypic Analysis of a Novel LncRNA (Na2) Expression on Arabidopsis thaliana Salinity Stress Response, Trang M. Trinh
Department: Biochemistry and Molecular Biology

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Development of a Modified 2-Picolyl Appended Triazolylidene-Ruthenium Complex for Examination of Hydrogen Bonding Effects in the Secondary Coordination Sphere for Direct Amidation Catalysis, Clark Wang
Department: Chemistry

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Raindrops, Benchtops: Method Development for the Detection of Metolachlor in Precipitation, Arielle Welch
Department: Chemistry

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Monitoring Protein Interactions between Ribonucleotide Reductase and Thioredoxin in Yeast Lacking Key Peroxiredoxins, Nicole West
Department: Biochemistry and Molecular Biology

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Watching Paint Dry: The Solvation and Separation of Paints Containing Carmine Lake Pigment, Samantha Wigley
Department: Chemistry

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Methods Development for the Characterization of Carbonyl Compounds in Rainwater and the Evaluation of Their Multiphase Reactions to Form Brown Carbon, Kevin A. Wokosin
Department: Chemistry

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Progress Towards the Diastereoselective Synthesis of a Single Diastereomer Dipeptide Analog in the Ugi Reaction via the Use of Chiral N-acylhydrazone Auxiliaries, Xingrong Zhu
Department: Chemistry

Senior Independent Study Theses from 2017

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Development of Mesoionic Carbene Ligands Containing Hydrogen-Bonding Functionalities for the Metal-Catalyzed Oxidative Coupling of Amines and Alcohols, Diego E. Arellano
Department: Chemistry

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Real-Time PCR Analysis of a Salt Stress Responsive LncRNA in Arabidopsis under Salt Stress Conditions, Peter J. Arts
Department: Biochemistry and Molecular Biology

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Improving p-XRF Capabilities for In Situ Geochemical Analysis: A Case Study of Arkansas's Magnet Cove and Stanley Shale, Elizabeth Backman
Department: Chemistry; Geology

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Characterizing Ribonucleotide Reductase's Role in Promoting Genomic Instability in tsa1Δ Mutants, Brianna L. Bauer
Department: Biochemistry and Molecular Biology

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Increasing Diversity in Chemistry and Environmental Education: Making Outdoor, Experiential Education more Accessible to High School Chemistry Teachers, Molly Dysis Billings
Department: Chemistry

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Mechanistic Investigation into the Liver Kinase β-1 – AMP-Activated Protein Kinase – Phosphagen Kinase Phosphorylation Cascade, Camille K. Boufford
Department: Biochemistry and Molecular Biology

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Investigating Changes in Protein Markers Following Sleep Deprivation in Drosophila Melanogaster, Petra N. Boutros
Department: Biochemistry and Molecular Biology; Neuroscience

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The Effect of pH on the Direct Photolysis of Warfarin in Aqueous Solution, Bailey B. Bowers
Department: Chemistry

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Effects of Metal Salts and Anoxia on the Photodegradation of Red Food Dyes, Catherine Boyles
Department: Chemistry

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Got Light? : A Study of the Physical Properties of Single-Layer Organic Light-Emitting Diode Devices Using a Poly(p-phenylene vinylene) Derivative, Harley Brandstadter
Department: Chemistry

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A genetic approach to examine how the Thioredoxin system influences genomic stability in S. cerevisiae, John Buchan
Department: Biochemistry and Molecular Biology

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Synthetic Progress Towards Regioselective Disulfide Bond Formation via Azide-Alkyne Cycloaddition, Zachary T. Buchan
Department: Chemistry

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Determining the effects of polyadenylation on long noncoding RNA expression and stability in response to stress, Allyson Caselberry
Department: Biochemistry and Molecular Biology

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The Evaluation of Organosilica Sorbent Media for the Removal of Perfluoroalkyl Compounds from Drinking Water, Rachel M. Collins
Department: Chemistry

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Progress Towards the Diastereoselective Synthesis of Dipeptide Analogs via the Use of Chiral N-acylhydrazone Auxiliaries in the Ugi Reaction, Anna V. Davies
Department: Chemistry

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Evidence of Differential Expression in the Calcineurin Gene Family in Paramecium Tetraurelia And Science in Fiction is not always Science Fiction: An analysis of the German Vergangenheitsbewältigungsliteratur through a Science Fiction Lens as a means to discredit Nazi Racial Science, Alexander G. Day
Department: Biochemistry and Molecular Biology; German Studies

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Exploring The Molecular Function of cAMP and Phosphodiesterase PDE1C during Axon Pathfinding in Drosophila Melanogaster, Alexandra R. Elchert
Department: Biochemistry and Molecular Biology

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Identification of Catalytic Residues in the 3C-like Protease of Maize chlorotic dwarf virus, Anna Emmick
Department: Biochemistry and Molecular Biology

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Development of a Novel Method of Unrestricted Polypeptide Synthesis Utilizing a Salicylaldehyde Based Auxiliary Molecule, Jake Eshelman
Department: Biochemistry and Molecular Biology

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Exploration of Palladium Catalyzed Cross-Coupling for the Synthesis of an Electroluminescent Polymer Model Compound, Leandra Forte
Department: Chemistry

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Assessing the Effects of Recombinant AK Genes on the Growth and Development of Myxococcus xanthus, Mark A. Grady
Department: Biochemistry and Molecular Biology

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Elucidating the Mechanism of the Oxidative Decarboxylation of 6-Hydroxynicotinate by 6-Hydroxynicotinate 3-Monooxygenase (NicC) Through Kinetic Analysis, Jack H. Harrington
Department: Chemistry

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A Brief Survey of the Metallic Properties of Electric Guitar Strings and Their Effects on Sound, Stephen Hause
Department: Chemistry

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Novel Synthesis of Difluorene Bisintercalators via Direct Amidation Using Swellable Organically Modified Silica (SOMS) and Employment of the CAN1 Forward Mutation Assay to Assess Mutagenicity, Hannah M. Hicks
Department: Biochemistry and Molecular Biology; Environmental Studies

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Investigation of Esterification Reactions in Swellable Organically Modified Silica Towards the Synthesis of Polyethylene Terephthalate, Kirstin M. Holm
Department: Chemistry

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Investigating the Potential Genetic Causes of the Marbled Phenotype in the Betta splendens, Jennifer Hurtig
Department: Biochemistry and Molecular Biology

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A Versatile Esterification Methodology Using Swellable Organically Modified Silica (SOMS) as Nano-Ractors, Hannah K. Huston
Department: Chemistry

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The Drosophila melanogaster polyadenosine RNA binding protein, Nab2, is necessary for survival and neural development, in a model of intellectual disability., Michael Kahl
Department: Biochemistry and Molecular Biology; Neuroscience

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Chemical Education Research Project: Helping Elementary School Teachers Inspire Their Students to Continue Learning Chemistry, Gretchen Kallmeyer
Department: Chemistry

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The Effect of a His Tag on IclR Interactions with DNA and Ligands in Escherichia coli, Mara A. Kingscott
Department: Biochemistry and Molecular Biology

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The Need for a New Style of Assessment in Introductory Chemistry Courses, Christopher LeCompte
Department: Chemistry

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The Effects of Male-Produced Adipokinetic Hormone I on the Fertility of Female Aedes aegypti, Anna L. McGlade
Department: Biochemistry and Molecular Biology

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Investigation of the Heck Reaction for the Synthesis of a Model Light-Emitting Copolymer, Angelo J. Melari
Department: Chemistry

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Substrate Specificity of Horseradish Peroxidase for the Oxidation of Pharmaceutical Compounds, Lance Metsger
Department: Biochemistry and Molecular Biology; Chemistry

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Investigation of Antidepressant Load Reduction Following Tertiary Wastewater Disinfection Treatment, Rachel A. Mole
Department: Chemistry

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Incoherent Broadband Cavity Enhanced Absorption Spectroscopy: Improving Sensitivity while Studying Solvent Effects in Benzene, Ryan W. Ostendorf
Department: Chemistry

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The Efficacy of Osorb® as a Catalyst Replacement for Friedel-Crafts Acylation, Alex Pearson
Department: Chemistry

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The Effect of Matrix Composition on the Photodegradation of Acetaminophen, Jake W. Polster
Department: Chemistry

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Allelochemical Extraction from Soil Using Swellable Organically Modified Silica, Adrienne Reding
Department: Biochemistry and Molecular Biology

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Development of Ruthenium (II)-Mesoionic Carbene Complexes for Investigation of Secondary Coordination Sphere Interactions in Homogeneous Catalysis, Lindsay L. Robinson
Department: Chemistry

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Investigating the Impact of Substituent Positioning on the Photochemistry of meta and ortho Aminobenzoic Acid Derivatives, Haley A. Rossiter
Department: Chemistry

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Biophysical Characterization of the Cofactors in the NicAB Complex from Bacillus niacini, Laura A. Sherer
Department: Biochemistry and Molecular Biology

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Modeling the Commitment to Senescence Through Mitochondrial Fusion and Chromosomal Restructuring, Herbert Sizek
Department: Biochemistry and Molecular Biology

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Analyzing H7 as a Possible Structural Determinant of Negative Cooperativity within the Phosphagen Kinase Enzyme Family, Katie Stock
Department: Biochemistry and Molecular Biology

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Investigating the Relationship Between Self-Interaction and Function of the Viral Suppressor of RNAi Expressed by Maize Chlorotic Dwarf Virus, Ben R. Stromberg
Department: Biochemistry and Molecular Biology

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Genetic Engineering of the GFP Coding Region for Expression of Fusion Proteins in Saccharomyces cerevisiae, Jenna S. Taira
Department: Biochemistry and Molecular Biology

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Differentiation of Anthraquinone-based Dyes and Pigments using Fluorescence, Madeline Rui Thomas
Department: Chemistry

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Characterizing the genetic determinants of the nicotinic acid degradation pathway in Bacillus niacini, Tsun Ki Jerrick To
Department: Biochemistry and Molecular Biology

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Desorption of Menthol from Swellable Organically Modified Silica: A Potential for Extended Transdermal Delivery Application, Todd P. Ulmer
Department: Chemistry

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Insecticide Fungicide Interaction and Synergistic Toxicity in Honey Bees, Andrea H. Wade
Department: Biochemistry and Molecular Biology

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The Fate of Pharmaceuticals: The Effects of Humic Acid on Amoxicillin's Rate of Photodegradation, Michael R. Whitaker
Department: Chemistry

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Investigating The Genetic Basis Of Melanistic Betta splendens, Harrison P. Wooten
Department: Biochemistry and Molecular Biology

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Evaluation of Organosilica Sebum Control Ingredients, Yaoyin Xu
Department: Chemistry

Senior Independent Study Theses from 2016

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Stabilizing Redox-Responsive Protein Network Interactions with a Thiol-Reactive Cross-Linker, Kristin M. Allan
Department: Biochemistry and Molecular Biology

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Differential Expression of a Novel lncRNA (Na2) Aids in Arabidopsis thaliana Survival Under High Salinity Stress, Michael D. Andes
Department: Biochemistry and Molecular Biology

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Solvent Effects on the Quantum Efficiencies and UV-induced Photodegradation of PABA and Padimate-O, Preetom Borah
Department: Chemistry; Music

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Evaluation of Organosilica-Iron Composites as A Soil Amendment to Protect Against Pesticide Drift, Taylor M. Bowen
Department: Chemistry

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Attempting to Identify the Calcium-Dependent Sodium Channel in Paramecium Tetraurelia, Thomas J. Camp
Department: Biochemistry and Molecular Biology; Neuroscience

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Cochineal: Connecting Chemistry and Religious Studies through the World of Art, Amanda Carmichael
Department: Chemistry; Religious Studies

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Biomimetic Adsorbents for the Removal of Microcystins from Water, Kimberly Anne Carter
Department: Chemistry

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License and Registration Please: The Development of an In-Field THC Detection Test Using a Hybrid-Bio-Inorganic Stationary Phase, Catherine Christian
Department: Chemistry

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An Investigation of Effective Methods to Form and Hydrolyze H-Phosphonate Diester Bonds for a Nucleophilic Acyl Substitution Reaction, Albert J. Darling
Department: Chemistry

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The Partial Characterization of a Monooxygenase in Bacillus niacini, Morgan A. Dasovich
Department: Biochemistry and Molecular Biology

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Analysis of Bioaccumulation and Sublethal Toxic Effects in Eisenia fetida, Lactuca sativa, and Arabidopsis thaliana Following Antidepressant Exposure, Rachael S. Davis
Department: Biochemistry and Molecular Biology

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Stimulating Encapsulated Fragrance Release by Malodor Absorption, Andrea Michelle DeMarsh
Department: Chemistry