The full text of Senior Independent Study Theses submitted during and after 2012 are available to download only by College of Wooster users. Unless listed as an exemplar, all other theses are restricted.

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Senior Independent Study Theses from 2016

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Stabilizing Redox-Responsive Protein Network Interactions with a Thiol-Reactive Cross-Linker, Kristin M. Allan
Department: Biochemistry and Molecular Biology

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Differential Expression of a Novel lncRNA (Na2) Aids in Arabidopsis thaliana Survival Under High Salinity Stress, Michael D. Andes
Department: Biochemistry and Molecular Biology

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Solvent Effects on the Quantum Efficiencies and UV-induced Photodegradation of PABA and Padimate-O, Preetom Borah
Department: Chemistry; Music

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Evaluation of Organosilica-Iron Composites as A Soil Amendment to Protect Against Pesticide Drift, Taylor M. Bowen
Department: Chemistry

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Cochineal: Connecting Chemistry and Religious Studies through the World of Art, Amanda Carmichael
Department: Chemistry; Religious Studies

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Biomimetic Adsorbents for the Removal of Microcystins from Water, Kimberly Anne Carter
Department: Chemistry

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License and Registration Please: The Development of an In-Field THC Detection Test Using a Hybrid-Bio-Inorganic Stationary Phase, Catherine Christian
Department: Chemistry

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An Investigation of Effective Methods to Form and Hydrolyze H-Phosphonate Diester Bonds for a Nucleophilic Acyl Substitution Reaction, Albert J. Darling
Department: Chemistry

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The Partial Characterization of a Monooxygenase in Bacillus niacini, Morgan A. Dasovich
Department: Biochemistry and Molecular Biology

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Analysis of Bioaccumulation and Sublethal Toxic Effects in Eisenia fetida, Lactuca sativa, and Arabidopsis thaliana Following Antidepressant Exposure, Rachael S. Davis
Department: Biochemistry and Molecular Biology

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Stimulating Encapsulated Fragrance Release by Malodor Absorption, Andrea Michelle DeMarsh
Department: Chemistry

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Got milk? An In-Depth Analysis of Community Water Fluoridation and a Chemical Investigation of Fluoridated Milk as an Alternative to Fluoridated Water, Shikha Dharia
Department: Biology; Chemistry; Interdepartmental

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Laying the Groundwork for Illuminating the Relationship Between Structure and Catalytic Efficiency in Phz O, a Phenazine Biosynthesis Enzyme, Leslie A. Doone
Department: Biochemistry and Molecular Biology

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Impact of medium, ambient environment, and surface on the UV-induced degradation of carmine lake, Erin Drake
Department: Chemistry

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Characterization of Long Non-Coding RNA Expression During Low Temperature Stress in Arabidopsis thaliana: Exploring the Implications of Targeting lncRNA for Improved Plant Growth, Ellyn Evans
Department: Biochemistry and Molecular Biology

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Evaluation of Polysilsesquioxane Materials as a Solid-State Electrolyte Matrix in Lithium-Ion Batteries, Jackson M. Fielder
Department: Chemistry

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The Elucidation of a Mechanism for Malonic Acid Photooxidation in Aqueous Solution, Nathan J. Gimble
Department: Chemistry

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Preliminary investigation of Caenorhabditis elegans arginine kinase phosphorylation by AMPK, Andrew H. Greene
Department: Biochemistry and Molecular Biology

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A Dynamical Systems Approach to Understanding Synergies Between Thyroid Cancer Mutations, Andrew R. Hamel
Department: Biochemistry and Molecular Biology

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Synthetic Progress Towards the Production of Hydroxymethyl and Mercaptomethyl Salicylaldehyde Derivatives for use in Protein Chemical Synthesis, Conner A. Hoelzel
Department: Biochemistry and Molecular Biology

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Progress Towards a Total Synthesis of Grandilodine C, Trevor Horst
Department: Chemistry

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Examination of Introductory Chemistry Education via Correlational Analysis of Student Performance and Psychological/Demographical Factors, Joshua K. Houtz
Department: Chemistry

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Development and Testing of the Sentinel Passive Samplers Designed for Integrative and Rapid Adsorption of Environmental Water Contaminants, Ellen A. Hudson-Heck
Department: Chemistry

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Investigating the Structural Features that Promote Peroxiredoxin-Sulfiredoxin Interactions in Yeast, Joseph E. Kelly
Department: Biochemistry and Molecular Biology

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Generation of a NicC Bordetella pertussis Mutant: Investigating the Relationship Between Nicotinic Acid Degradation and Virulence Modulation, Melia Kovach
Department: Biochemistry and Molecular Biology

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Attempted Identification of the Calcium-Dependent Sodium Channel Gene in Paramecium tetraurelia using RNAi, Gwendolyn Kuzmishin
Department: Biochemistry and Molecular Biology

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Attempted Synthesis of 2,3,6-Trihydroxypyridine and Characterization of the Putative Ring-Cleavage Enzyme in Bacillus niacini Nicotinate Catabolism, Nicholas P. Lesner
Department: Chemistry

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Molecular Basis for Suppression of Genomic Instability by a Conserved Peroxidase, Matthew A. Loberg
Department: Biochemistry and Molecular Biology

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Photodegradation of p-aminobenzoic acid in different ambient and pH environments and stabilization by antioxidants, Briana E. Marlatt
Department: Chemistry

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Investigation of the Functionality of the Nicotinic Acid Degradation Pathway of Bordetella pertussis as a Potential Treatment for Whooping Cough, Dylan L. McCreary
Department: Chemistry

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Transdermal Drug Delivery Using Organosilica Encapsulants, Elizabeth McInturf
Department: Chemistry

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Deciphering the Metal Dependency of Novel Nicotinic Acid Dehydrogenase from Bacillus niacini, Jessica A. Meek
Department: Biochemistry and Molecular Biology

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Examining Evolution of Substrate Specificity Using Taurocyamine Kinase, Huyen Thai Ngoc Nguyen
Department: Biochemistry and Molecular Biology

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Horseradish Peroxidase Entrapped in Organically Modified Silica for the Degradation of Endocrine Disrupting Compounds in Drinking Water, Jonathan E. Nutt
Department: Biochemistry and Molecular Biology

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Horseradish peroxidase entrapped in organically modified silica for the degradation of endocrine disrupting compounds in drinking water, Jonathan E. Nutt
Department: Biochemistry and Molecular Biology

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Identification of Genes Involved in Exoprotease Activity in Pseudomonas chlororaphis (14B11), Jennifer M. Pilat
Department: Biochemistry and Molecular Biology

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Exploring the Effects of Sleep Deprivation on Gene Expression in Drosophila Melanogaster, Kate M. Redding
Department: Biochemistry and Molecular Biology; Neuroscience

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Requirement of Nab2 RNA Binding in Drosophila melanogaster Nervous System Development, Fatima L. Rodriguez
Department: Biochemistry and Molecular Biology; Neuroscience

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Mechanistic Investigation of the Ugi Reaction and Evaluation of Diastereomeric Control via Chiral Isocyanides, Peter J. Rohweder
Department: Chemistry

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Investigating the proposed acid-base catalyzed mechanism for 6-hydroxynicotinate 3-monooxygenase (NicC)., Alvi N. Sakib
Department: Biochemistry and Molecular Biology

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The Effect of Solvent and Acceptor on Hydrogen Bonds Between Benzyl Alcohol - Aromatic Systems, Michael H. Schlueter
Department: Chemistry

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Synthesis of a potential phosphatidylserine Analog: cis-1,4-Cyclohexyldiphosphoserine, Traci A. Scott
Department: Chemistry

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Investigating the Targets of Plant Pathogen RXLR Effectors Through Hypersensitivity to Stress Conditions in Saccharomyces cerevisiae, Colleen Elizabeth Sells
Department: Biochemistry and Molecular Biology

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The Putative Regulatory Role of Hydrogen Cyanide in Ethylene Signaling and Biosynthesis in Arabidopsis seedlings and tomato fruit, Heather Skinner
Department: Biochemistry and Molecular Biology

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Enhancing the Bioavailibility of the Dietary Supplement Curcumin through Nanodispersions, Kevin B. Smith Jr
Department: Chemistry

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Synthesis of a Potential Phospholipid Analog: trans-1,4-cyclohexane-diphosphoserine, Abby Szlachta
Department: Chemistry

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Effects of Arginine Kinase Gene Deletions on Muscle Physiology and Mitochondrial Volume in Caenorhabditis Elegans, Kathryn Timar
Department: Biochemistry and Molecular Biology

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Theory and Synthesis of Heterobimetallic Catalysts Towards Nitrogen Fixation, Joseph R. Whiston
Department: Chemistry

Senior Independent Study Theses from 2015

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Altering amino acid residues at the dimer interface of the yeast peroxiredoxin Ahp1: Effects on quaternary structure and protection against peroxides, Jonathan K. Allotey
Department: Biochemistry and Molecular Biology

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Investigation Into the Role of the Poly(A) Binding and Regulating Protein dNab2 in the Mushroom Bodies of Drosophila Melanogaster, Zachariah A. Brewer
Department: Biochemistry and Molecular Biology

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Virulence Modulation of Bordetella Pertussis via Inhibition of the Nicotinate Degradation Pathway, Lauren Buyan
Department: Biochemistry and Molecular Biology; Neuroscience

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Elucidating the Degradation Pathway of Venlafaxine(Effexor), Naveeshini Nair Chandran
Department: Biochemistry and Molecular Biology

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A Comparative Assessment of Venlafaxine Degradation in Municipal and Industrial Wastewater Treatment Plant Sludge, Shauntia Cobb
Department: Biology; Chemistry; Environmental Studies

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Cloning and Expression of the Novel Proteins in the Bacillus niacini Nicotinic Acid Degradation Pathway and an Initial Attempt to Characterize the NicAB Complex, Abigail K. Daniel
Department: Biochemistry and Molecular Biology

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Mechanistic Insights into the Suppression of Mutations by the Yeast Peroxiredoxin Tsa1, Joseph B. David
Department: Biochemistry and Molecular Biology

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Assessment and Comparison of Ornamental Plant Disease Resistance and Plant Growth as Effected by Microbial Inoculants, Tylar Fisk
Department: Biochemistry and Molecular Biology

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Assessing Mechanistic Proposals of 6-Hydroxynicotinate 3- Monooxygenase (NicC) from B. bronchiseptica, Tyler J. Gerwig
Department: Chemistry

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Optimization and Characterization of Swellable Organically Modified Silica Particles for the Extraction of Volatile Fatty Acids, Alyssa Gilbert
Department: Biochemistry and Molecular Biology

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Xerogel-Coated Sand for the Adsorption and Enzymatic Degradation of Micropollutants in Drinking Water Treatment Plants, Emily J. Gleason
Department: Biochemistry and Molecular Biology

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A Molecular Analysis of Root-knot Nematode Nutrient Uptake, Allison B. Grenell
Department: Biochemistry and Molecular Biology

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Understanding the Origin of Swelling Force in Organically Modified Silica, Evan J. Hagedorn
Department: Chemistry; Physics

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The Effects of pH on the Hydroxyl Radical Reaction with Aqueous Malonic Acid, Rachelle P. Herrin
Department: Chemistry

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Investigating the Impact of Monofunctional and Bifunctional Electrophiles on Cellular Proteasome Activity, Brandon L. James
Department: Biochemistry and Molecular Biology

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Exploring the Structural Basis for Negative Cooperativity in the Phosphagen Kinase Superfamily, Gentry Jarrett Kerwood
Department: Biochemistry and Molecular Biology

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Investigating the Hydrogenphosphonate Diester Intermediate of a Potential Phosphatidylserine Analog: Cyclohexylphosphoserine, Ryan M. Kish
Department: Chemistry

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Modification of Saccharomyces cerevisiae oxidant defense proteins by the electrophiles N- ethylmaleimide and parthenolide, Karis Kosar
Department: Biochemistry and Molecular Biology

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Toward an ether-functionalized calix[4]arene for improved solubility in polar solvents, Virginia C. Lungerich
Department: Chemistry

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Inhibition and Kinetic Isotope Effect Studies to Further Characterize the Mechanism of Maleamate Amidohydrolase (NicF), Karan Malani
Department: Biochemistry and Molecular Biology

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Analysis of Byproduct Formation during the Disinfection Process of Wastewater Treatment, Derrick Marshall
Department: Chemistry

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Dosing on Demand: Enhanced Ibuprofen Release by an Organosilica Encapsulant, Noel Mellor
Department: Chemistry

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Synthesis and Characterization of Rhenium(I) Tricarbonyl Bromide Complexes as Potential Photodynamic Therapy Agents, Mason M. Mendenhall
Department: Chemistry

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Quantitative Determination of the New Antidepressant Vortioxetine in Wastewater Effluent by LC-MS/MS Analysis, Claire E. Moffett
Department: Chemistry

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Synthesis of the Proposed Phosphatidylserine Analogs: 4-tert-butylcyclohexylphosphoserine and trans-1,4-cyclohexyldiphosphoserine, Kyle W. Murray
Department: Chemistry

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Supported Pd-Catalysts for Hydrodechlorination of Trichloroethylene Using a Continuous Flow Liquid Phase Reactor, Eric R. Painting
Department: Chemistry

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XH-π bonding in systems of indole and benzene using IBBCEAS and a bioinformatics analysis of protein secondary structure using graph theory, Meredith Schervish
Department: Chemistry; Mathematics

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The Quantitative Determination of Antidepressants and their Primary Degradation Products in Pre and Post “Quasar” treatment and in Lagoon Sludge Destined for Land Application, Kristina M. Schiavone
Department: Chemistry

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Cloning, Purification, and Analysis of an Aromatic Monooxygenase Protein Involved in the Production of Strain-Specific Phenazine Metabolites, Edmund W. Shi
Department: Biochemistry and Molecular Biology

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Preliminary Investigation of Arginine Kinase in Caenorhabditis elegans, Dempsey J. Simonis
Department: Biochemistry and Molecular Biology

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Synthesis and Characterization of Potential Antitumor Transition Metals, Donald J. Sullivan Jr
Department: Chemistry

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A Screen for S. cerevisiae Mutants Hypersensitive to the P. sojae effector PsAvh172, Matthew J. Sydor
Department: Biochemistry and Molecular Biology

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Development of Azobenzocrown Ethers as Selective Photoresponsive Supramolecular Host by way of a Novel Photoassisted Synthetic Step, Lucas C. Webber
Department: Chemistry

Senior Independent Study Theses from 2014

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Transcriptional Response to the Phytophthora Sojae Avh110 Effector Protein Using a Yeast Expression Study, Gabriel J. Abud
Department: Biochemistry and Molecular Biology

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Investigating the Effects of Small Molecule Inhibitors of Potassium Channels on Mortality Rate and Urine Excretion in Female Aedes aegypti, Sheila O. Amoako
Department: Biochemistry and Molecular Biology

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Evolution of Negative Cooperativity in Phosphagen Kinases, Manish Aryal
Department: Biochemistry and Molecular Biology

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An In-Depth Analysis of the Photophysical Properties of para-Aminobenzoic Acid and 4-Dimethylaminobenzoic Acid, Jacob A. Boroff
Department: Chemistry

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Photochemical Degradation of the Carmine Dye Molecule in Artist Media, Leah M.R. Bowers
Department: Chemistry

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Two And Three Dimensional Ising Model Based Graphical User-Interphase Simulator: User-Friendly Ising Model Simulator, Norman Chamusah
Department: Chemistry; Computer Science

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Electrophilic Modification of Methionine Sulfoxide Reductases - Mxr1 and Ykg9 from Baker's Yeast, Juliet Chepngeno
Department: Biochemistry and Molecular Biology

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A Scientific Paradigm Shift from Reductionism to Holism: The Potential Relationship between Nicotinate Degradation and Virulence Modulation in Bordetella pertussis, Pailin Chiaranunt
Department: Biochemistry and Molecular Biology; Philosophy

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Optimization of a SBSE-LC-MS/MS Method for the Determination of Endocrine Disrupting Chemicals in Environmental Aqueous Samples, Allison E. Chin
Department: Chemistry

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Examining a Role for Thioredoxin in Protecting Against Protein Damage by Isothiocyanate-Containing Electrophiles, Sreyan Chowdhury
Department: Biochemistry and Molecular Biology

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An Analysis of the Bioremediaiton of Venlafaxine, James B. Claybourne IV
Department: Biochemistry and Molecular Biology

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LC-MS/MS Analysis of Fluoxetine and Serotonin-Related Compounds in Eisenia Fetida Living in Treated Soil, Maria Dawaher
Department: Biochemistry and Molecular Biology; Chemistry

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The Fate of the Formic Acid Radical: A Kinetic Investigation of the Reaction Between Oxalic Acid and the Hydroxyl Radical, Lauren T. Fleming
Department: Chemistry

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Effect of Growth Selection on Adipogenic Gene Expression in Turkey Breast Muscle, Kory K. George
Department: Biochemistry and Molecular Biology

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Toward an Efficient Synthesis of N-Substituted Hydroxypyrrole Monomers, Jenna L. Gnotek
Department: Chemistry

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Molecular Biology of a Miracle: Conceptualization of Medicine Through the Amish-Religious Lens and Antimicrobial Properties of Burdock Burn Wound Treatment, Caroline H. Gormley
Department: Biochemistry and Molecular Biology; Religious Studies

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Towards the Optimization of Amide Bond Coupling in the Synthesis of FRET Enabled Hairpin Polyamides, Kaitlin M. Graham
Department: Chemistry

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The Quantitative Determination of Antidepressants and Their Primary Degradation Products in Biosolid-Amended Soil and Earthworms via LC-MS/MS analysis, Maura J. Hall
Department: Chemistry

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Sythesis and Purification of Bis-Phosphoserine-Cyclohexyl Lipid Analogues Utilizing an H-Phosphonate Approach, Steven A. Hardy
Department: Chemistry